Designed ankyrin repeat proteins (DARPins): binding proteins for research, diagnostics, and therapy
A Plückthun - Annual review of pharmacology and toxicology, 2015 - annualreviews.org
Designed ankyrin repeat proteins (DARPins) can recognize targets with specificities and
affinities that equal or surpass those of antibodies, but because of their robustness and …
affinities that equal or surpass those of antibodies, but because of their robustness and …
Arming antibodies: prospects and challenges for immunoconjugates
AM Wu, PD Senter - Nature biotechnology, 2005 - nature.com
Immunoconjugates—monoclonal antibodies (mAbs) coupled to highly toxic agents,
including radioisotopes and toxic drugs (ineffective when administered systemically alone) …
including radioisotopes and toxic drugs (ineffective when administered systemically alone) …
Bifunctional coupling agents for radiolabeling of biomolecules and target-specific delivery of metallic radionuclides
S Liu - Advanced drug delivery reviews, 2008 - Elsevier
Receptor-based radiopharmaceuticals are of great current interest in molecular imaging and
radiotherapy of cancers, and provide a unique tool for target-specific delivery of …
radiotherapy of cancers, and provide a unique tool for target-specific delivery of …
CORM‐A1: a new pharmacologically active carbon monoxide‐releasing molecule
Carbon monoxide (CO) is emerging as an important and versatile mediator of physiological
processes to the extent that treatment of animals with exogenous CO gas has beneficial …
processes to the extent that treatment of animals with exogenous CO gas has beneficial …
Synthesis and Properties of Boranocarbonate: A Convenient in Situ CO Source for the Aqueous Preparation of [99mTc(OH2)3(CO)3]+
The recently described technetium (I) complex [99mTc (OH2) 3-(CO) 3]+ 1 has attracted
much interest as a precursor for technetium-99m radiopharmaceuticals. 1 A number of …
much interest as a precursor for technetium-99m radiopharmaceuticals. 1 A number of …
Technetium and gallium derived radiopharmaceuticals: comparing and contrasting the chemistry of two important radiometals for the molecular imaging era
MD Bartholoma, AS Louie, JF Valliant… - Chemical …, 2010 - ACS Publications
The objective of medical imaging using molecular probes and perfusion radiotracers is to
provide rapid, noninvasive evaluation of physiology, pathology, and/or organ function. The …
provide rapid, noninvasive evaluation of physiology, pathology, and/or organ function. The …
Antibody engineering
▪ Abstract Antibodies are unique in their high affinity and specificity for a binding partner, a
quality that has made them one of the most useful molecules for biotechnology and …
quality that has made them one of the most useful molecules for biotechnology and …
Early phase I study of a 99mTc-labeled anti–programmed death ligand-1 (PD-L1) single-domain antibody in SPECT/CT assessment of PD-L1 expression in non–small …
Y **ng, G Chand, C Liu, GJR Cook… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Immunotherapy with checkpoint inhibitor programmed cell death 1 (PD-1)/programmed
death ligand-1 (PD-L1) antibodies demonstrates improvements in treatment of advanced …
death ligand-1 (PD-L1) antibodies demonstrates improvements in treatment of advanced …
Antibodies and genetically engineered related molecules: production and purification
Antibodies and antibody derivatives constitute 20% of biopharmaceutical products currently
in development, and despite early failures of murine products, chimeric and humanized …
in development, and despite early failures of murine products, chimeric and humanized …
Bioinspired thiophosphorodichloridate reagents for chemoselective histidine bioconjugation
Site-selective bioconjugation to native protein residues is a powerful tool for protein
functionalization, with cysteine and lysine side chains being the most common points for …
functionalization, with cysteine and lysine side chains being the most common points for …