Fast synaptic communication in the brain requires synchronous vesicle fusion that is evoked
by action potential-induced Ca2+ influx. However, synaptic terminals also release …

Neurotransmission is sustained by endocytosis and refilling of synaptic vesicles (SVs)
locally within the presynapse. Until recently, a consensus formed that after exocytosis, SVs …

Most neuronal communication relies upon the synchronous release of neurotransmitters,
which occurs through synaptic vesicle exocytosis triggered by action potential invasion of a …

Upon entering a presynaptic terminal, an action potential opens Ca2+ channels, and
transiently increases the local Ca2+ concentration at the presynaptic active zone. Ca2+ then …

The molecular organization of presynaptic active zones during calcium influx–triggered
neurotransmitter release is the focus of intense investigation. The Drosophila coiled-coil …

Synaptic vesicle recycling is one of the best‐studied cellular pathways. Many of the proteins
involved are known, and their interactions are becoming increasingly clear. However, as for …

Activity deprivation in neurons induces a slow compensatory scaling up of synaptic strength,
reflecting a homeostatic mechanism for stabilizing neuronal activity. Prior studies have …

Despite the pronounced neurological deficits associated with mental retardation and autism,
it is unknown if altered neocortical circuit function occurs in these prevalent disorders. Here …

The impact of spontaneous neurotransmission on neuronal plasticity remains poorly
understood. Here, we show that acute suppression of spontaneous NMDA receptor …

Ca2+ triggers many forms of exocytosis in different types of eukaryotic cells, for example
synaptic vesicle exocytosis in neurons, granule exocytosis in mast cells, and hormone …