Lentiviral vector bioprocessing

C Perry, ACME Rayat - Viruses, 2021 - mdpi.com
Lentiviral vectors (LVs) are potent tools for the delivery of genes of interest into mammalian
cells and are now commonly utilised within the growing field of cell and gene therapy for the …

Nanometrics goes beyond the size: Assessment of nanoparticle concentration and encapsulation efficiency in nanocarriers

SS Marques, MA Segundo - TrAC Trends in Analytical Chemistry, 2024 - Elsevier
Nanoparticle concentration and encapsulation efficiency (EE) are critical attributes for the
efficacy/toxicity of nanoformulations for human use. Consequently, their assessment at …

[HTML][HTML] Synthesis of iron, zinc, and manganese nanofertilizers, using Andean blueberry extract, and their effect in the growth of cabbage and lupin plants

E Murgueitio-Herrera, CE Falconí, L Cumbal, J Gómez… - Nanomaterials, 2022 - mdpi.com
The predominant aim of the current study was to synthesize the nanofertilizer nanoparticles
ZnO_MnO-NPs and FeO_ZnO-NPs using Andean blueberry extract and determine the effect …

Human glioblastoma-derived cell membrane nanovesicles: A novel, cell-specific strategy for boron neutron capture therapy of brain tumors

A Balboni, G Ailuno, S Baldassari, G Drava… - Scientific Reports, 2024 - nature.com
Glioblastoma (GBM), one of the deadliest brain tumors, accounts for approximately 50% of
all primary malignant CNS tumors, therefore novel, highly effective remedies are urgently …

Characterization of recombinant adeno-associated viruses (rAAVs) for gene therapy using orthogonal techniques

L Cole, D Fernandes, MT Hussain, M Kaszuba… - Pharmaceutics, 2021 - mdpi.com
Viruses are increasingly used as vectors for delivery of genetic material for gene therapy
and vaccine applications. Recombinant adeno-associated viruses (rAAVs) are a class of …

Development of functionally relevant potency assays for monovalent and multivalent vaccines delivered by evolving technologies

G Sanyal - npj Vaccines, 2022 - nature.com
A potency or potency-indicating assay is a regulatory requirement for the release of every lot
of a vaccine. Potency is a critical quality attribute that is also monitored as a stability indicator …

Submicron-precision particle characterization in microfluidic impedance cytometry with double differential electrodes

J Zhong, M Liang, Y Ai - Lab on a Chip, 2021 - pubs.rsc.org
Submicron-precision particle characterization is crucial for counting, sizing and identifying a
variety of biological particles, such as bacteria and apoptotic bodies. Microfluidic impedance …

Nanoplastics from disposable paper cups and microwavable food containers

JW Son, Y Nam, C Kim - Journal of Hazardous Materials, 2024 - Elsevier
Abstract Nanoplastics (NPs,< 1 µm) pose greater risks due to their increased absorption
rates in biological systems. In this study, we investigated the release of NPs from paper cups …

Development of nanofibers with embedded liposomes containing an immunomodulatory drug using green electrospinning

L Casula, A Zidar, J Kristl, M Jeras, S Kralj, AM Fadda… - Pharmaceutics, 2023 - mdpi.com
Conventional treatments for chronic wounds are often ineffective, thus new therapeutic
approaches are needed, such as the delivery of immunomodulatory drugs that can reduce …

Diffusion of gold nanoparticles in porous silica monoliths determined by dynamic light scattering

W Wu, J Cui, U Sultan, L Gromotka, P Malgaretti… - Journal of Colloid and …, 2023 - Elsevier
Hypothesis The applicability of the dynamic light scattering method for the determination of
particle diffusivity under confinement without applying refractive index matching was not …