Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies

M Liu, BL de Juan Abad, K Cheng - Advanced drug delivery reviews, 2021 - Elsevier
Cardiac fibrosis remains an unresolved problem in heart diseases. After initial injury, cardiac
fibroblasts (CFs) are activated and subsequently differentiate into myofibroblasts (myoFbs) …

RNA-based diagnostic and therapeutic strategies for cardiovascular disease

D Lu, T Thum - Nature Reviews Cardiology, 2019 - nature.com
Cardiovascular diseases are the leading cause of death globally and are associated with
increasing financial expenditure. With the availability of next-generation sequencing …

Functional screening identifies miRNAs inducing cardiac regeneration

A Eulalio, M Mano, MD Ferro, L Zentilin, G Sinagra… - Nature, 2012 - nature.com
In mammals, enlargement of the heart during embryonic development is primarily
dependent on the increase in cardiomyocyte numbers. Shortly after birth, however …

MicroRNAs: roles in cardiovascular development and disease

S Kalayinia, F Arjmand, M Maleki, M Malakootian… - Cardiovascular …, 2021 - Elsevier
Cardiovascular diseases (CVDs) comprise a group of disorders ranging from peripheral
artery, coronary artery, cardiac valve, cardiac muscle, and congenital heart diseases to …

Pervasive roles of microRNAs in cardiovascular biology

EM Small, EN Olson - Nature, 2011 - nature.com
First recognized as regulators of development in worms and fruitflies, microRNAs are
emerging as pivotal modulators of mammalian cardiovascular development and disease …

MicroRNAs in heart failure: from biomarker to target for therapy

EL Vegter, P van der Meer, LJ de Windt… - European journal of …, 2016 - Wiley Online Library
MicroRNAs (miRNAs) are increasingly recognized to play important roles in cardiovascular
diseases, including heart failure. These small, non‐coding RNAs have been identified in …

Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies

BC Bernardo, KL Weeks, L Pretorius… - Pharmacology & …, 2010 - Elsevier
Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …

The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy

A Ucar, SK Gupta, J Fiedler, E Erikci… - Nature …, 2012 - nature.com
Pathological growth of cardiomyocytes (hypertrophy) is a major determinant for the
development of heart failure, one of the leading medical causes of mortality worldwide. Here …

Circulating microRNAs are new and sensitive biomarkers of myocardial infarction

Y D'alessandra, P Devanna, F Limana… - European heart …, 2010 - academic.oup.com
Abstract Aims Circulating microRNAs (miRNAs) may represent a novel class of biomarkers;
therefore, we examined whether acute myocardial infarction (MI) modulates miRNAs plasma …

Mammalian microRNAs: experimental evaluation of novel and previously annotated genes

HR Chiang, LW Schoenfeld, JG Ruby… - Genes & …, 2010 - genesdev.cshlp.org
MicroRNAs (miRNAs) are small regulatory RNAs that derive from distinctive hairpin
transcripts. To learn more about the miRNAs of mammals, we sequenced 60 million small …