β-lactam antibiotics: An overview from a medicinal chemistry perspective
LM Lima, BNM da Silva, G Barbosa… - European journal of …, 2020 - Elsevier
Abstract β-Lactam antibiotics are one of the most relevant drug classes of antibacterial
agents worldwide. The discovery and the market of first β-lactam antibiotic (Penicillin G) is a …
agents worldwide. The discovery and the market of first β-lactam antibiotic (Penicillin G) is a …
Recent aspects of the effects of zinc on human health
Zinc (Zn) is one of the most important essential nutrients of great public health significance. It
is involved in numerous biological functions and it is considered as a multipurpose trace …
is involved in numerous biological functions and it is considered as a multipurpose trace …
Antimicrobial resistance: more than 70 years of war between humans and bacteria
SF Nadeem, UF Gohar, SF Tahir… - Critical Reviews in …, 2020 - Taylor & Francis
Abstract Development of antibiotic resistance in bacteria is one of the major issues in the
present world and one of the greatest threats faced by mankind. Resistance is spread …
present world and one of the greatest threats faced by mankind. Resistance is spread …
Plasmid evolution in carbapenemase‐producing Enterobacteriaceae: a review
K Kopotsa, J Osei Sekyere… - Annals of the New York …, 2019 - Wiley Online Library
Carbapenem‐resistant Enterobacteriaceae (CRE) have been listed by the WHO as high‐
priority pathogens owing to their high association with mortalities and morbidities …
priority pathogens owing to their high association with mortalities and morbidities …
New carbapenemase inhibitors: clearing the way for the β-lactams
Carbapenem resistance is a major global health problem that seriously compromises the
treatment of infections caused by nosocomial pathogens. Resistance to carbapenems …
treatment of infections caused by nosocomial pathogens. Resistance to carbapenems …
β-lactam/β-lactamase inhibitor combinations: an update
Antibiotic resistance caused by β-lactamase production continues to present a growing
challenge to the efficacy of β-lactams and their role as the most important class of clinically …
challenge to the efficacy of β-lactams and their role as the most important class of clinically …
Metallo-ß-lactamases: a review
Microbial pathogens including Enterobacteriaceae family members bear different antibiotic
resistance genes comprising Extended-Spectrum-ß-Lactamases (ESBLs) and Metallo-ß …
resistance genes comprising Extended-Spectrum-ß-Lactamases (ESBLs) and Metallo-ß …
Cefiderocol antimicrobial susceptibility testing against multidrug-resistant Gram-negative bacilli: a comparison of disk diffusion to broth microdilution
CP Morris, Y Bergman, T Tekle, JA Fissel… - Journal of clinical …, 2020 - Am Soc Microbiol
Antimicrobial susceptibility testing (AST) of cefiderocol poses challenges because of its
unique mechanism of action (ie, requiring an iron-depleted state) and due to differences in …
unique mechanism of action (ie, requiring an iron-depleted state) and due to differences in …
Emerging Transcriptional and Genomic Mechanisms Mediating Carbapenem and Polymyxin Resistance in Enterobacteriaceae: a Systematic Review of Current …
The spread of carbapenem-and polymyxin-resistant Enterobacteriaceae poses a significant
threat to public health, challenging clinicians worldwide with limited therapeutic options. This …
threat to public health, challenging clinicians worldwide with limited therapeutic options. This …
Computationally designed peptide macrocycle inhibitors of New Delhi metallo-β-lactamase 1
The rise of antibiotic resistance calls for new therapeutics targeting resistance factors such
as the New Delhi metallo-β-lactamase 1 (NDM-1), a bacterial enzyme that degrades β …
as the New Delhi metallo-β-lactamase 1 (NDM-1), a bacterial enzyme that degrades β …