DNA and RNA can adopt various secondary structures. Four-stranded G-quadruplex (G4)
structures form through self-recognition of guanines into stacked tetrads, and considerable …

It has been> 20 years since the formation of G-quadruplex (G4) secondary structures in
gene promoters was first linked to the regulation of gene expression. Since then, the …

Guanine-rich DNA sequences can fold into four-stranded, noncanonical secondary
structures called G-quadruplexes (G4s). G4s were initially considered a structural curiosity …

The first large genome fully sequenced by next-generation sequencing (NGS) was that of a
bacteriophage using sequencing by synthesis (SBS) as a paradigm. SBS in NGS is …

The response to DNA damage is critical for cellular homeostasis, tumor suppression,
immunity, and gametogenesis. In order to provide an unbiased and global view of the DNA …

DNA structure can regulate genome function. Four-stranded DNA G-quadruplex (G4)
structures have been implicated in transcriptional regulation; however, previous studies …

Guanine-rich sequences can form G-quadruplexes (G4) in living cells, making these
structures promising anti-cancer targets. Compounds able to recognize these structures …

Substantial evidence now exists to support that formation of DNA G-quadruplexes (G4s) is
coupled to altered gene expression. However, approaches that allow us to probe G4s in …

Metazoan promoters are enriched in secondary DNA structure-forming motifs, such as G-
quadruplexes (G4s). Here we describe 'G4access', an approach to isolate and sequence …

Genomic maps of DNA G-quadruplexes (G4s) can help elucidate the roles that these
secondary structures play in various organisms. Herein, we employ an improved version of a …