Nucleosome positioning is critical for gene expression and most DNA-related processes.
Here we review the dominant patterns of nucleosome positioning that have been observed …

Ribosomal protein genes are among the most highly expressed genes in most cell types.
Their products are generally essential for ribosome synthesis, which is the cornerstone for …

Despite extensive research, our understanding of the rules according to which cis-regulatory
sequences are converted into gene expression is limited. We devised a method for …

Although the genetic code is redundant, synonymous codons for the same amino acid are
not used with equal frequencies in genomes, a phenomenon termed “codon usage bias.” …

A veritable explosion of primary research papers within the past 10 years focuses on
nucleolar and ribosomal stress, and for good reason: with ribosome biosynthesis …

Background Ribosomes are highly conserved molecular machines whose core composition
has traditionally been regarded as invariant. However, recent studies have reported …

The 5′-untranslated region (5′-UTR) of mRNAs contains elements that affect expression,
yet the rules by which these regions exert their effect are poorly understood. Here, we …

Understanding how precise control of gene expression is specified within regulatory DNA
sequences is a key challenge with far-reaching implications. Many studies have focused on …

Data of gene expression levels across individuals, cell types, and disease states is
expanding, yet our understanding of how expression levels impact phenotype is limited …

Most genes change expression levels across conditions, but it is unclear which of these
changes represents specific regulation and what determines their quantitative degree. Here …