Third-generation sequencing: the spearhead towards the radical transformation of modern genomics
Although next-generation sequencing (NGS) technology revolutionized sequencing, offering
a tremendous sequencing capacity with groundbreaking depth and accuracy, it continues to …
a tremendous sequencing capacity with groundbreaking depth and accuracy, it continues to …
The evolution, assembly, and dynamics of marine Holobionts
The holobiont concept (ie, multiple living beings in close symbiosis with one another and
functioning as a unit) is revolutionizing our understanding of biology, especially in marine …
functioning as a unit) is revolutionizing our understanding of biology, especially in marine …
Identification of nucleoside monophosphates and their epigenetic modifications using an engineered nanopore
Y Wang, S Zhang, W Jia, P Fan, L Wang, X Li… - Nature …, 2022 - nature.com
RNA modifications play critical roles in the regulation of various biological processes and
are associated with many human diseases. Direct identification of RNA modifications by …
are associated with many human diseases. Direct identification of RNA modifications by …
[HTML][HTML] Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing
Alternative splicing is a post-transcriptional regulatory mechanism producing distinct mRNA
molecules from a single pre-mRNA with a prominent role in the development and function of …
molecules from a single pre-mRNA with a prominent role in the development and function of …
In response to abiotic stress, DNA methylation confers epigenetic changes in plants
Epigenetics involves the heritable changes in patterns of gene expression determined by
developmental and abiotic stresses, ie, drought, cold, salinity, trace metals, and heat. Gene …
developmental and abiotic stresses, ie, drought, cold, salinity, trace metals, and heat. Gene …
Nanopore sequencing of RNA and cDNA molecules in Escherichia coli
High-throughput sequencing dramatically changed our view of transcriptome architectures
and allowed for ground-breaking discoveries in RNA biology. Recently, sequencing of full …
and allowed for ground-breaking discoveries in RNA biology. Recently, sequencing of full …
HydraPsiSeq: a method for systematic and quantitative map** of pseudouridines in RNA
Develo** methods for accurate detection of RNA modifications remains a major challenge
in epitranscriptomics. Next-generation sequencing-based map** approaches have …
in epitranscriptomics. Next-generation sequencing-based map** approaches have …
Advances in mRNA 5-methylcytosine modifications: Detection, effectors, biological functions, and clinical relevance
G Guo, K Pan, S Fang, L Ye, X Tong, Z Wang… - … Therapy-Nucleic Acids, 2021 - cell.com
5-methylcytosine (m 5 C) post-transcriptional modifications affect the maturation, stability,
and translation of the mRNA molecule. These modifications play an important role in many …
and translation of the mRNA molecule. These modifications play an important role in many …
New insights into Arabidopsis transcriptome complexity revealed by direct sequencing of native RNAs
Arabidopsis thaliana transcriptomes have been extensively studied and characterized under
different conditions. However, most of the current 'RNA-sequencing'technologies produce a …
different conditions. However, most of the current 'RNA-sequencing'technologies produce a …
Measuring the tail: Methods for poly (A) tail profiling
A Brouze, PS Krawczyk… - Wiley Interdisciplinary …, 2023 - Wiley Online Library
Abstract The 3′‐end poly (A) tail is an important and potent feature of most mRNA
molecules that affects mRNA fate and translation efficiency. Polyadenylation is a …
molecules that affects mRNA fate and translation efficiency. Polyadenylation is a …