N-terminal acetylation (Nt-acetylation) is a widespread protein modification among
eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino …

N-terminal acetylation (NTA) is one of the most abundant protein modifications known, and
the N-terminal acetyltransferase (NAT) machinery is conserved throughout all Eukarya. Over …

Connective tissue growth factor (CCN2/CTGF) is a matricellular protein that is
overexpressed in progressive human renal diseases, mainly in fibrotic areas. In vitro studies …

SAM domain and HD domain containing protein 1 (SAMHD1) is a deoxynucleotide
triphosphohydrolase (dNTPase) that inhibits retroviruses by depleting intracellular …

Nα-terminal acetylation (NTA) is a prevalent protein modification in eukaryotes. In plants, the
biological function of NTA remains enigmatic. The dominant N-acetyltransferase (Nat) in …

Cancer is a major global health problem that disrupts the balance of normal cellular growth
and behavior. Mounting evidence has shown that epigenetic modification, specifically N …

Genomic imprinting is an allelic gene expression phenomenon primarily controlled by allele-
specific DNA methylation at the imprinting control region (ICR), but the underlying …

N-α-acetyltransferase 10 (NAA10) is an acetyltransferase that acetylates both N-terminal
amino acid and internal lysine residues of proteins. NAA10 is a crucial player to regulate cell …

Hepatocellular carcinoma (HCC), a representative example of a malignancy with a poor
prognosis, is characterized by high mortality because it is typically in an advanced stage at …

Arrest defective 1 (ARD1), also known as N (alpha)-acetyltransferase 10 (NAA10) was
originally identified as an N-terminal acetyltransferase (NAT) that catalyzes the acetylation of …