β-Carboline-based molecular hybrids as anticancer agents: A brief sketch
Cancer is a huge burden on the healthcare system and is foremost cause of mortality across
the globe. Among various therapeutic strategies, chemotherapy plays an enormous role in …
the globe. Among various therapeutic strategies, chemotherapy plays an enormous role in …
Progress in the Synthesis of Fused 1, 2, 3‐Triazoles
Fused heterocycles display prodigious prominence in diverse field ranging from medicinal
chemistry to material science and chemical biology to catalysis. Owing to biological …
chemistry to material science and chemical biology to catalysis. Owing to biological …
Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation
Psoriasis is an autoimmune skin disease, where chronic immune responses due to
exaggerated cytokine signaling, abnormal differentiation, and evasion of keratinocytes …
exaggerated cytokine signaling, abnormal differentiation, and evasion of keratinocytes …
[HTML][HTML] Nimbolide protects against endotoxin-induced acute respiratory distress syndrome by inhibiting TNF-α mediated NF-κB and HDAC-3 nuclear translocation
Acute respiratory distress syndrome (ARDS) is characterized by an excessive acute
inflammatory response in lung parenchyma, which ultimately leads to refractory hypoxemia …
inflammatory response in lung parenchyma, which ultimately leads to refractory hypoxemia …
Exploration of carbamide derived pyrimidine-thioindole conjugates as potential VEGFR-2 inhibitors with anti-angiogenesis effect
The development of new small molecules from known structural motifs through molecular
hybridization is one of the trends in drug discovery. In this connection, we have combined …
hybridization is one of the trends in drug discovery. In this connection, we have combined …
Design and synthesis of substituted dihydropyrimidinone derivatives as cytotoxic and tubulin polymerization inhibitors
An operationally simple Biginelli protocol was employed for the synthesis of new C6-carbon
based aryl α-haloacrylamide-linked dihydropyrimidinone derivatives. The synthesized …
based aryl α-haloacrylamide-linked dihydropyrimidinone derivatives. The synthesized …
Design and Synthesis of DNA‐Interactive β‐Carboline–Oxindole Hybrids as Cytotoxic and Apoptosis‐Inducing Agents
A new series of (E)‐3‐[(1‐aryl‐9H‐pyrido [3, 4‐b] indol‐3‐yl) methylene] indolin‐2‐one
hybrids were synthesized and evaluated for their in vitro cytotoxic activity against a panel of …
hybrids were synthesized and evaluated for their in vitro cytotoxic activity against a panel of …
Benzimidazole based bis-carboxamide derivatives as promising cytotoxic agents: Design, synthesis, in silico and tubulin polymerization inhibition
A new series of carboxamide-bearing benzimidazole derivatives have been reported for
their cytotoxicity profile (in vitro) on selected human tumour cells like A549, HCT116, SK-Mel …
their cytotoxicity profile (in vitro) on selected human tumour cells like A549, HCT116, SK-Mel …
Synthesis and in vitro cytotoxicity evaluation of β-carboline-linked 2, 4-thiazolidinedione hybrids: potential DNA intercalation and apoptosis-inducing studies
A series of new β-carboline-thiazolidinedione hybrids was synthesized and assessed for in
vitro cytotoxicity potential against selected human cancer cell lines, namely, PC-3, A549, MG …
vitro cytotoxicity potential against selected human cancer cell lines, namely, PC-3, A549, MG …
Synthesis of 1, 2, 4-triazole-linked urea/thiourea conjugates as cytotoxic and apoptosis inducing agents
Abstract A new series of 1, 2, 4-triazole-linked urea and thiourea conjugates have been
synthesized and evaluated for their in vitro cytotoxicity against selected human cancer cell …
synthesized and evaluated for their in vitro cytotoxicity against selected human cancer cell …