Pretargeted nuclear imaging and radiotherapy have recently attracted increasing attention
for diagnosis and treatment of cancer with nanomedicines. This is because it conceptually …

Stimuli-responsive polymeric depots capable of on-demand release of therapeutics promise
a substantial improvement in the treatment of many local diseases. These systems have the …

Due to their rapid and highly selective nature, bioorthogonal chemistry reactions are
attracting a significant amount of recent interest in the radiopharmaceutical community. Over …

Pretargeting is a multi-step process that first has an unlabeled bispecific antibody (bsMAb)
localize within a tumor by virtue of its anti-tumor binding site (s) before administering a small …

The article reviews the background and current status of pretargeting for cancer imaging and
therapy with radionuclides. Pretargeting procedures were introduced∼ 20 years ago as an …

With the approval of 2 radiolabeled antibody products for the treatment of non-Hodgkin's
lymphoma (NHL), radioimmunotherapy (RIT) has finally come of age as a new therapeutic …

A novel, promising strategy for cancer diagnosis and therapy is the use of a pretargeting
approach. For this purpose, the non-natural DNA/RNA analogues Peptide Nucleic Acids …

Pretargeting is often used as a tumor targeting strategy that provides much higher tumor to
non-tumor ratios than direct-targeting using radiolabeled antibody. Due to the multiple …

Pretargeting is a promising strategy to reach high imaging contrast in a shorter time than by
targeting with directly radiolabeled monoclonal antibodies (mAbs). One of problems in …

There is a compelling need to image pancreas cancer at an early stage. Human pancreas
cancer cells display elevated levels of KRAS protein due to high copy numbers of KRAS …