[HTML][HTML] TGF-β signaling in health and disease

J Massagué, D Sheppard - Cell, 2023‏ - cell.com
The TGF-β regulatory system plays crucial roles in the preservation of organismal integrity.
TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury …

Metastasis

S Gerstberger, Q Jiang, K Ganesh - Cell, 2023‏ - cell.com
Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis
as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still …

Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies

Q Zhou, Y Meng, D Li, L Yao, J Le, Y Liu… - Signal transduction and …, 2024‏ - nature.com
Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

Y Huang, W Hong, X Wei - Journal of hematology & oncology, 2022‏ - Springer
Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …

The current state of the art and future trends in RAS-targeted cancer therapies

SR Punekar, V Velcheti, BG Neel… - Nature reviews Clinical …, 2022‏ - nature.com
Despite being the most frequently altered oncogenic protein in solid tumours, KRAS has
historically been considered 'undruggable'owing to a lack of pharmacologically targetable …

Cancers make their own luck: theories of cancer origins

A Jassim, EP Rahrmann, BD Simons… - Nature Reviews …, 2023‏ - nature.com
Cancer has been a leading cause of death for decades. This dismal statistic has increased
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …

PI3K/Akt/mTOR pathway and its role in cancer therapeutics: are we making headway?

Y Peng, Y Wang, C Zhou, W Mei, C Zeng - Frontiers in oncology, 2022‏ - frontiersin.org
Cancer is a severe public health issue that is a leading cause of mortality globally. It is also
an impediment to improving life expectancy worldwide. Furthermore, the global burden of …

rMATS-turbo: an efficient and flexible computational tool for alternative splicing analysis of large-scale RNA-seq data

Y Wang, Z **e, E Kutschera, JI Adams… - Nature …, 2024‏ - nature.com
Pre-mRNA alternative splicing is a prevalent mechanism for diversifying eukaryotic
transcriptomes and proteomes. Regulated alternative splicing plays a role in many …

Dynamic EMT: a multi‐tool for tumor progression

S Brabletz, H Schuhwerk, T Brabletz… - The EMBO journal, 2021‏ - embopress.org
The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …

Unveiling the mechanisms and challenges of cancer drug resistance

SU Khan, K Fatima, S Aisha, F Malik - Cell Communication and Signaling, 2024‏ - Springer
Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer
treatment strategies are evolving due to innate and acquired resistance capacity, governed …