Allergic rhinitis (AR), chronic rhinosinusitis (CRS) and asthma often co‐exist. The one airway
model proposes that disease mechanisms occurring in the upper airway may mirror lower …

The common disease asthma is probably not a single disease, but rather a complex of
multiple, separate syndromes that overlap. Although clinicians have recognised these …

While asthma is considered an inflammatory disorder of the conducting airways, it is
becoming increasingly apparent that the disease is heterogeneous with respect to …

Spirometric measures of lung function are heritable traits that reflect respiratory health and
predict morbidity and mortality. We meta-analyzed genome-wide association studies for two …

Airway smooth muscle (ASM) plays an integral part in the pathophysiology of asthma. It is
responsible for acute bronchoconstriction, which is potentiated by constrictor …

There has been a recent increase in the prevalence of asthma worldwide; however, the 5–
10% of patients with severe disease account for a substantial proportion of the health costs …

Severe asthma exacerbations are periods of intense airway inflammation that have been
hypothesised to contribute to structural changes in the airways. If so, accelerated lung …

Severe asthma remains poorly understood and frustrating to care for, partly because it is a
heterogeneous disease. Patients with severe asthma disproportionately consume health …

Asthma and chronic obstructive pulmonary disease (COPD) are characterised by airflow
obstruction, airway remodelling (measurable structural change) and inflammation. The …

Background Periostin, an extracellular matrix protein, contributes to subepithelial thickening
in asthmatic airways, and its serum levels reflect airway eosinophilic inflammation. However …