Background Nowadays, conventional medical treatments such as surgery, radiotherapy, and
chemotherapy cannot cure all types of cancer. A promising approach to treat solid tumors is …

The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …

The application of microbial strains as axenic cultures has frequently been employed in a
diverse range of sectors. In the natural environment, microbes exist as multispecies and …

During microbial applications, metabolic burdens can lead to a significant drop in cell
performance. Novel synthetic biology tools or multi-step bioprocessing (eg, fermentation …

Cell proliferation is a fundamental requirement for organismal development and
homeostasis. The mammalian cell division cycle is tightly controlled to ensure complete and …

Tissue repair, immune defence and cancer progression rely on a vital cellular decision
between quiescence and proliferation,. Mammalian cells proliferate by triggering a positive …

The genus Euphorbia is one of the largest genera in the spurge family, with diversity in
range, distribution, and morphology. The plant species in this genus are widely used in …

At the restriction point (R), mammalian cells irreversibly commit to divide. R has been viewed
as a point in G1 that is passed when growth factor signaling initiates a positive feedback …

The cell cycle is canonically described as a series of four consecutive phases: G1, S, G2,
and M. In single cells, the duration of each phase varies, but the quantitative laws that …

The coordination of cell proliferation with reversible cell cycle exit into quiescence is crucial
for the development of multicellular organisms and for tissue homeostasis in the adult. The …