Hyperpigmentation disorders constitute important medical and aesthetical conditions. Dark
areas or dark spots on the skin result from inappropriate amount and/or deposition of skin …

L-DOPA is an amino acid that is used as a treatment for Parkinson's disease. A simple
enzymatic synthesis method of L-DOPA had been developed using bacterial L-tyrosine …

The group I alkali metal ions Na+ and K+ are ubiquitous components of biological fluids that
surround biological macromolecules. They play important roles other than being nonspecific …

The chemical synthesis of 3‐substituted tyrosine derivatives requires a minimum of four
steps to access optically enriched material starting from commercial precursors. Attempting …

Leinamycin (LNM) is a sulfur-containing antitumor antibiotic featuring an unusual 1, 3-dioxo-
1, 2-dithiolane moiety that is spiro-fused to a thiazole-containing 18-membered lactam ring …

The key step in the enzymatic reaction catalyzed by tyrosine phenol-lyase (TPL) is reversible
cleavage of the Cβ–Cγ bond of l-tyrosine. Here, we present X-ray structures for two …

YGL196W of Saccharomyces cerevisiae encodes a putative protein that is unidentified but is
predicted to have a motif similar to that of the N-terminal domain of the bacterial alanine …

Enzymes with high catalytic activity and stability are essential for industrial production, yet
most natural enzymes do not meet these requirements. Therefore, efficient strategies for …

Amino acid transformations catalyzed by a number of pyridoxal 5′-phosphate (PLP)-
dependent enzymes involve abstraction of the Cα proton from an external aldimine formed …

The tyrosine phenol‐lyase from Symbiobacterium toebii was engineered to improve both its
stability and catalytic activity by the application of random mutagenesis and subsequent …