Biopolymers based aerogels: A review on revolutionary solutions for smart therapeutics delivery

HPSA Khalil, EB Yahya, F Jummaat, AS Adnan… - Progress in Materials …, 2023 - Elsevier
Biopolymers-based aerogels have gained the attention of many scientists in medical and
pharmaceutical applications. Biopolymers-based aerogels are utilized extensively in the …

Advances in oral drug delivery systems: Challenges and opportunities

J Lou, H Duan, Q Qin, Z Teng, F Gan, X Zhou, X Zhou - Pharmaceutics, 2023 - mdpi.com
The oral route is the most preferred route for systemic and local drug delivery. However, the
oral drug delivery system faces the harsh physiological and physicochemical environment of …

Enhanced oral bioavailability from food protein nanoparticles: A mini review

T Zhang, L Li, S Chunta, W Wu, Z Chen, Y Lu - Journal of Controlled …, 2023 - Elsevier
The oral route is the most desirable drug administration path. The oral bioavailability is
always compromised from the poor physicochemical and/or biopharmaceutical properties of …

Liposomes for oral delivery of protein and peptide-based therapeutics: Challenges, formulation strategies, and advances

A Jash, A Ubeyitogullari, SSH Rizvi - Journal of Materials Chemistry B, 2021 - pubs.rsc.org
Throughout the past decade, there has been a rapid growth in the development of
protein/peptide-based therapeutics. These therapeutics have found widespread applications …

Co-delivery of insulin and quercetin in W/O/W double emulsions stabilized by different hydrophilic emulsifiers

L Han, K Lu, S Zhou, B Qi, Y Li - Food Chemistry, 2022 - Elsevier
Insulin (hydrophilic) and quercetin (hydrophobic) have broad biological benefits; however,
their rapid hydrolysis (via protease degradation) during digestion hinders their stability and …

C2C12 cell model: its role in understanding of insulin resistance at the molecular level and pharmaceutical development at the preclinical stage

CY Wong, H Al-Salami, CR Dass - Journal of Pharmacy and …, 2020 - academic.oup.com
Objectives The myoblast cell line, C2C12, has been utilised extensively in vitro as an
examination model in understanding metabolic disease progression. Although it is …

Natural polysaccharide-based nanodrug delivery systems for treatment of diabetes

A Qiu, Y Wang, G Zhang, H Wang - Polymers, 2022 - mdpi.com
In recent years, natural polysaccharides have been considered as the ideal candidates for
novel drug delivery systems because of their good biocompatibility, biodegradation, low …

Production of high loading insulin nanoparticles suitable for oral delivery by spray drying and freeze drying techniques

Y Guo, A Baldelli, A Singh, F Fathordoobady, D Kitts… - Scientific reports, 2022 - nature.com
Insulin nanoparticles (NPs) with high loading content have found diverse applications in
different dosage forms. This work aimed to evaluate the impact of freeze-drying and spray …

Recent progress in design and preparation of glucose-responsive insulin delivery systems

D Shen, H Yu, L Wang, A Khan, F Haq, X Chen… - Journal of Controlled …, 2020 - Elsevier
Diabetes, as a global threat nowadays, causes the wide usage of exogenous insulin.
Subcutaneous injection is the traditional insulin administration in the diabetes treatments …

Drug delivery system in the treatment of diabetes mellitus

R Zhao, Z Lu, J Yang, L Zhang, Y Li… - … in bioengineering and …, 2020 - frontiersin.org
Diabetes mellitus has been described as a chronic endocrine and metabolic disease, which
is characterized by hyperglycemia and the coexistence of multiple complications. At present …