The dawn of the 21st century has brought with it a surge of research related to computer-
guided approaches to catalyst design. In the past two decades, chemoinformatics, the …

This review covers recent developments relating to organocatalyzed transformations by
chiral isothioureas (ITUs) since their original introduction by Birman in 2006. This class of …

Enantiopure Si-stereogenic organosilanes are highly valued in the fields of organic
synthesis, development of advanced materials, and drug discovery. However, they are not …

The chemical sciences are witnessing an influx of statistics into the catalysis literature.
These developments are propelled by modern technological advancements that are leading …

Enantioselective copper (I) hydride (CuH)-catalyzed hydroamination has undergone
significant development over the past several years. To gain a general understanding of the …

Triarylsilanols have been reported as the first silicon-centered molecular catalysts for direct
amidation of carboxylic acids with amines as identified after a screen of silanols, silanediols …

A polystyrene-supported isothiourea (1a) behaves as a highly efficient organocatalyst in a
variety of formal [4+ 2] cycloaddition reactions. The catalytic system has proven to be highly …

The enantioselective silylation of racemic alcohols, where one enantiomer reacts faster than
the other, is an alternative approach to established enzymatic and non-enzymatic acylation …

The non‐enzymatic kinetic resolution of racemic mixtures of alcohols by silylation had been
unknown before the turn of the century. This stands in stark contrast to established acylation …

In recent years, remarkable progress has been made in the enantioselective silylation of
alcohols. Owing to the successful site‐and stereoselective functionalization of hydroxy …