Immunoglobulin has been widely used in a variety of diseases, including primary and
secondary immunodeficiency diseases, neuromuscular diseases, and Kawasaki disease …

The humoral immune response provides specific, long-lived protection against invading
pathogens, via immunoglobulin production and other memory functions. IgG, the most …

Given the global surge in autoimmune diseases, it is critical to evaluate emerging
therapeutic interventions. Despite numerous new targeted immunomodulatory therapies …

Human IgG is the main antibody class used in antibody therapies because of its efficacy and
longer half-life, which are completely or partly due to FcγR-mediated functions of the …

Pathogenic immunoglobulin G (IgG) autoantibodies characterize some human autoimmune
diseases; their high concentration and long half-life are dependent on recycling by the …

Almost all therapeutic proteins are glycosylated, with the carbohydrate component playing a
long-established, substantial role in the safety and pharmacokinetic properties of this …

The neonatal fragment crystallizable (Fc) receptor (FcRn) functions as a recycling
mechanism to prevent degradation and extend the half-life of IgG and albumin in the …

Objectives: Identify the mechanism of action of intravenous immunoglobulin. Describe the
potential adverse effects of intravenous immunoglobulin. Review the appropriate monitoring …

Systemic autoimmune and inflammatory diseases have a complex and only partially known
pathophysiology with various abnormalities involving all the components of the immune …

Nonspecific orbital inflammation (NSOI), colloquially known as orbital pseudotumor,
sometimes presents a diagnostic and therapeutic challenge in ophthalmology. This review …