Tissue-specific progenitor cells are characterized by proliferation and differentiation, but, in
contrast to embryonic stem (ES) cells, have limited capacities for self-renewal and no …

With the increasing success of islet transplantation, β‐cell replacement therapy has had
renewed interest. To make such a therapy available to more than a few of the thousands of …

Introduction Fibrosis, or scar formation, is a pathological condition characterized by
excessive production and accumulation of collagen, loss of tissue architecture, and organ …

The clonal isolation of putative adult pancreatic precursors has been an elusive goal of
researchers seeking to develop cell replacement strategies for diabetes. We report the …

Background There is a widespread interest in develo** renewable sources of islet-
replacement tissue for type I diabetes mellitus. Human mesenchymal cells isolated from the …

Type I diabetes mellitus is caused by an autoimmune destruction of the insulin‐producing β
cells. The major obstacle in using transplantation for curing the disease is the limited source …

We show that muscle satellite cells, traditionally considered as committed myogenic
precursors, are comprised of Pax7-expressing progenitors that preserve a mesenchymal …

Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated
mice lacking Irs2 in β cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all …

Nestin is a type VI intermediate filament protein originally described in neural stem cells.
Here we report that immature endothelial cells generated in the course of angiogenesis …

Aside from traditional neurotransmission and regulation of secretion, γ-amino butyric acid
(GABA) through GABAA receptors negatively regulates proliferation of pluripotent and …