Malaria parasite liver infection and exoerythrocytic biology
AM Vaughan, SHI Kappe - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
In their infection cycle, malaria parasites undergo replication and population expansions
within the vertebrate host and the mosquito vector. Host infection initiates with sporozoite …
within the vertebrate host and the mosquito vector. Host infection initiates with sporozoite …
The apicoplast: now you see it, now you don't
Parasites such as Plasmodium and Toxoplasma possess a vestigial plastid homologous to
the chloroplasts of algae and plants. The plastid (known as the apicoplast; for apicomplexan …
the chloroplasts of algae and plants. The plastid (known as the apicoplast; for apicomplexan …
Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass …
Malaria parasite infection is initiated by the mosquito-transmitted sporozoite stage, a highly
motile invasive cell that targets hepatocytes in the liver for infection. A promising approach to …
motile invasive cell that targets hepatocytes in the liver for infection. A promising approach to …
Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites
Plasmodium sporozoites are transmitted from infected mosquitoes to mammals, and must
navigate the host skin and vasculature to infect the liver. This journey requires distinct …
navigate the host skin and vasculature to infect the liver. This journey requires distinct …
Phosphatidic acid-mediated signaling regulates microneme secretion in Toxoplasma
The obligate intracellular lifestyle of apicomplexan parasites necessitates an invasive phase
underpinned by timely and spatially controlled secretion of apical organelles termed …
underpinned by timely and spatially controlled secretion of apical organelles termed …
A kalihinol analog disrupts apicoplast function and vesicular trafficking in P. falciparum malaria
Z Chahine, S Abel, T Hollin, GL Barnes, JH Chung… - Science, 2024 - science.org
We report the discovery of MED6-189, an analog of the kalihinol family of isocyanoterpene
natural products that is effective against drug-sensitive and drug-resistant Plasmodium …
natural products that is effective against drug-sensitive and drug-resistant Plasmodium …
The flexibility of Apicomplexa parasites in lipid metabolism
Apicomplexa are obligate intracellular parasites responsible for major human infectious
diseases such as toxoplasmosis and malaria, which pose social and economic burdens …
diseases such as toxoplasmosis and malaria, which pose social and economic burdens …
Evolution of galactoglycerolipid biosynthetic pathways–from cyanobacteria to primary plastids and from primary to secondary plastids
Photosynthetic membranes have a unique lipid composition that has been remarkably well
conserved from cyanobacteria to chloroplasts. These membranes are characterized by a …
conserved from cyanobacteria to chloroplasts. These membranes are characterized by a …
[HTML][HTML] Fatty acid metabolism in the Plasmodium apicoplast: Drugs, doubts and knockouts
The malaria parasite Plasmodium possesses a relict, non-photosynthetic plastid known as
the apicoplast. The apicoplast is essential for parasite survival, and harbors several plant …
the apicoplast. The apicoplast is essential for parasite survival, and harbors several plant …
Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection
Within the liver a single Plasmodium parasite transforms into thousands of blood-infective
forms to cause malaria. Here, we use RNA-sequencing to identify host genes that are …
forms to cause malaria. Here, we use RNA-sequencing to identify host genes that are …