Microfluidic technologies employ nano and microscale fabrication techniques to develop
highly controllable and reproducible fluidic microenvironments. Utilizing microfluidics, lead …

A significant growth of research in nanofluidics is achieved over the past decade, but the
field is still facing considerable challenges toward the transition from the current physics …

Nanofluidic structures have over the last two decades emerged as a powerful platform for
detailed analysis of DNA on the kilobase pair length scale. When DNA is confined to a …

The ability to create complex three-dimensional microstructures has reached an
unprecedented level of sophistication in the last 15 years. For the most part, this is the result …

Abstract Background The Jurkat cell line has an extensive history as a model of T cell
signaling. But at the turn of the 21st century, some expression irregularities were observed …

In recent years, applications and experimental studies of DNA in nanochannels have
stimulated the investigation of the polymer physics of DNA in confinement. Recent advances …

Optical DNA map** has over the last decade emerged as a very powerful tool for
obtaining long range sequence information from single DNA molecules. In optical DNA …

Based on the online method, the absorption kinetics and mass transfer of CO 2 in potassium
carbonate solution in a serpentine minichannel are studied. Three flow patterns are …

Highlights•Single-molecule (SM) analysis is critical for studying heterogeneous biological
systems.•Microfluidics offers a wide range of tools for precise and efficient sample …

Primary Examiner Frank W Lu (57) ABSTRACT Systems and methods for nucleic acid
sequencing are pro vided. Nucleic acid is fixed in double-stranded linearized stretched form …