Hyperhomocysteinemia/Homocysteinuria is characterized by an increased level of toxic
homocysteine in the plasma. The plasma concentration of homocysteine is 5–15 μmol/L in …

Acute lymphoblastic leukemia (ALL) is diagnosed in 3000 to 4000 persons in the United
States each year; two thirds of them are children. 1, 2 The current rate of cure of nearly 80 …

As the cure rates for haematological malignancies have improved, the exploration of the
balance between efficacy and side effects has become a major research target. The …

Childhood leukemia is the most common cause of malignancy under the age of 15,
representing an annual incidence rate of 43 cases per million in the United States …

Abstract High hyperdiploidy (51–67 chromosomes) is the most common cytogenetic
abnormality pattern in childhood B‐cell precursor acute lymphoblastic leukemia (ALL) …

Polymorphisms in folate pathway genes may influence the susceptibility to acute
lymphoblastic leukemia (ALL). DNA was isolated from 245 pediatric ALL patients (cases) …

BACKGROUND Genetic susceptibility studies of lymphoma may serve to identify at risk
populations and to elucidate important disease mechanisms. METHODS This review …

To evaluate the contribution of candidate gene association studies to the understanding of
genetic susceptibility to childhood acute lymphoblastic leukemia we conducted a systematic …

Identifying genes involved in the development of cancer is crucial to fully understanding
cancer biology, for develo** novel therapeutics for cancer treatment and for providing …

Aim: Pharmacogenetics of methotrexate (MTX) contributes to interindividual differences in
toxicity. We aimed to evaluate the impact of SNPs within the MTX pathway genes on MTX …