The growth of siRNA-based therapeutics: Updated clinical studies
More than two decades after the natural gene-silencing mechanism of RNA interference was
elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the …
elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the …
Inherited retinal diseases: linking genes, disease-causing variants, and relevant therapeutic modalities
N Schneider, Y Sundaresan, P Gopalakrishnan… - Progress in retinal and …, 2022 - Elsevier
Inherited retinal diseases (IRDs) are a clinically complex and heterogenous group of visual
impairment phenotypes caused by pathogenic variants in at least 277 nuclear and …
impairment phenotypes caused by pathogenic variants in at least 277 nuclear and …
CRISPR interference (CRISPRi) for sequence-specific control of gene expression
Sequence-specific control of gene expression on a genome-wide scale is an important
approach for understanding gene functions and for engineering genetic regulatory systems …
approach for understanding gene functions and for engineering genetic regulatory systems …
Programmable RNA recognition and cleavage by CRISPR/Cas9
The CRISPR-associated protein Cas9 is an RNA-guided DNA endonuclease that uses RNA–
DNA complementarity to identify target sites for sequence-specific double-stranded DNA …
DNA complementarity to identify target sites for sequence-specific double-stranded DNA …
Nanotechnological approaches in prostate cancer therapy: integration of engineering and biology
Nanocarriers have received special attention in biomedicine for the treatment of various
diseases, especially cancer, as one of the leading causes of death worldwide. Nanocarriers …
diseases, especially cancer, as one of the leading causes of death worldwide. Nanocarriers …
The implication of long non-coding RNAs in the diagnosis, pathogenesis and drug resistance of pancreatic ductal adenocarcinoma and their possible therapeutic …
Pancreatic ductal adenocarcinoma (PDAC) is one of the lethal malignancies with the lowest
median and overall survival rate among all human malignancies. The major problems with …
median and overall survival rate among all human malignancies. The major problems with …
Pullulan: A novel molecule for biomedical applications
Pullulan is an imperative natural polymer produced commercially by yeast like fungus
Aureobasidium pullulans. It is non-toxic, non-immunogenic, non-carcinogenic and non …
Aureobasidium pullulans. It is non-toxic, non-immunogenic, non-carcinogenic and non …
Pullulan and pullulan derivatives as promising biomolecules for drug and gene targeting
Pullulan is a water soluble exo-polysaccharide produced by yeast like fungus
Aureobasidium pullulans. Pullulan structure have a unique characteristic ie co-existence of …
Aureobasidium pullulans. Pullulan structure have a unique characteristic ie co-existence of …
Fungal exopolysaccharides: Properties, sources, modifications, and biomedical applications
Fungal exopolysaccharides (EPSs) are natural biopolymers with diverse potential
applications in the biomedical, packaging, cosmetic, and food industries. Fungal EPSs are …
applications in the biomedical, packaging, cosmetic, and food industries. Fungal EPSs are …
Generating single cell–derived knockout clones in mammalian cells with CRISPR/Cas9
CRISPR/Cas9 technology enables the rapid generation of loss‐of‐function mutations in a
targeted gene in mammalian cells. A single cell harboring those mutations can be used to …
targeted gene in mammalian cells. A single cell harboring those mutations can be used to …