The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid
tissues, producing long-lived antibody secreting plasma cells and memory B cells, which …

Abstract The T helper 17 (Th17) cells contain a dynamic subset of CD4+ T-cells that are able
to develop into other different lineage subsets, including the Th1-like Th17 cells. These cells …

Co-ordinated interaction between distinct cell types is a hallmark of successful immune
function. A striking example of this is the carefully orchestrated cooperation between helper …

Vaccines are a highly effective intervention for conferring protection against infections and
reducing the associated morbidity and mortality in vaccinated individuals. However, ageing …

Red blood cell (RBC) transfusions can result in alloimmunization toward RBC alloantigens
that can increase the probability of complications following subsequent transfusion. An …

Vaccination is an excellent strategy to limit the morbidity and mortality associated with
infectious disease. Vaccination creates protective, long-lived antibody-mediated immunity by …

Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in
response to vaccination, producing long-lived antibody secreting plasma cells and memory …

Costimulation pathways play an essential role in T cell activation, differentiation, and
regulation. CD155 expressed on antigen-presenting cells (APCs) interacts with TIGIT, an …

T follicular helper (TFH) cells are critical in adaptive immune responses to pathogens and
vaccines; however, what drives the initiation of their developmental program remains …

We used functional-omics angles and examined transcriptomic heterogeneity in CD4+
Foxp3+ regulatory T cells (Treg) from spleen (s-Treg), lymph nodes (LN-Treg), intestine (int …