Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities
Covering: 2010 to 2021 Organisms in nature have evolved into proficient synthetic chemists,
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …
Dereplication: racing to speed up the natural products discovery process
Covering: 1993–2014 (July) To alleviate the dereplication holdup, which is a major
bottleneck in natural products discovery, scientists have been conducting their research …
bottleneck in natural products discovery, scientists have been conducting their research …
Retrospective analysis of natural products provides insights for future discovery trends
Understanding of the capacity of the natural world to produce secondary metabolites is
important to a broad range of fields, including drug discovery, ecology, biosynthesis, and …
important to a broad range of fields, including drug discovery, ecology, biosynthesis, and …
[HTML][HTML] Elicitation of secondary metabolism in actinomycetes
Genomic sequence data have revealed the presence of a large fraction of putatively silent
biosynthetic gene clusters in the genomes of actinomycetes that encode for secondary …
biosynthetic gene clusters in the genomes of actinomycetes that encode for secondary …
Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?
Microbial genome mining is a rapidly develo** approach to discover new and novel
secondary metabolites for drug discovery. Many advances have been made in the past …
secondary metabolites for drug discovery. Many advances have been made in the past …
Artificial intelligence in microbial natural product drug discovery: current and emerging role
Covering: up to the end of 2022 Microorganisms are exceptional sources of a wide array of
unique natural products and play a significant role in drug discovery. During the golden era …
unique natural products and play a significant role in drug discovery. During the golden era …
Drugs and drug candidates from marine sources: An assessment of the current “state of play”
DJ Newman, GM Cragg - Planta medica, 2016 - thieme-connect.com
The potential of the marine environment to produce candidate compounds (structures) as
leads to, or even direct drugs from, has been actively discussed for the last 50 or so years …
leads to, or even direct drugs from, has been actively discussed for the last 50 or so years …
Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species
Genome sequencing has revealed that bacteria contain many more biosynthetic gene
clusters than predicted based on the number of secondary metabolites discovered to date …
clusters than predicted based on the number of secondary metabolites discovered to date …
Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites
Covering: 2000 to 2016 The labor-intensive process of microbial natural product discovery is
contingent upon identifying discrete secondary metabolites of interest within complex …
contingent upon identifying discrete secondary metabolites of interest within complex …
Marine pharmacology in 2012–2013: Marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral …
The peer-reviewed marine pharmacology literature from 2012 to 2013 was systematically
reviewed, consistent with the 1998–2011 reviews of this series. Marine pharmacology …
reviewed, consistent with the 1998–2011 reviews of this series. Marine pharmacology …