Short-chain fatty acids and their association with signalling pathways in inflammation, glucose and lipid metabolism

J He, P Zhang, L Shen, L Niu, Y Tan, L Chen… - International journal of …, 2020 - mdpi.com
Short-chain fatty acids (SCFAs), particularly acetate, propionate and butyrate, are mainly
produced by anaerobic fermentation of gut microbes. SCFAs play an important role in …

[HTML][HTML] Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity

H Yoon, JL Shaw, MC Haigis, A Greka - Molecular cell, 2021 - cell.com
Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular
membranes, and regulate energy metabolism. Questions remain as to which lipid species …

Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease

D Erny, N Dokalis, C Mezö, A Castoldi, O Mossad… - Cell Metabolism, 2021 - cell.com
As tissue macrophages of the central nervous system (CNS), microglia constitute the pivotal
immune cells of this organ. Microglial features are strongly dependent on environmental …

Dietary lipids, gut microbiota and lipid metabolism

M Schoeler, R Caesar - Reviews in endocrine and metabolic disorders, 2019 - Springer
The gut microbiota is a central regulator of host metabolism. The composition and function of
the gut microbiota is dynamic and affected by diet properties such as the amount and …

Gut–liver axis: barriers and functional circuits

O Pabst, MW Hornef, FG Schaap, V Cerovic… - Nature Reviews …, 2023 - nature.com
The gut and the liver are characterized by mutual interactions between both organs, the
microbiome, diet and other environmental factors. The sum of these interactions is …

Metabolism and metabolic disorders and the microbiome: the intestinal microbiota associated with obesity, lipid metabolism, and metabolic health—pathophysiology …

J Aron-Wisnewsky, MV Warmbrunn, M Nieuwdorp… - Gastroenterology, 2021 - Elsevier
Changes in the intestinal microbiome have been associated with obesity and type 2
diabetes, in epidemiological studies and studies of the effects of fecal transfer in germ-free …

Risk assessment with gut microbiome and metabolite markers in NAFLD development

H Leung, X Long, Y Ni, L Qian, E Nychas… - Science translational …, 2022 - science.org
A growing body of evidence suggests interplay between the gut microbiota and the
pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, the role of the gut …

What defines a healthy gut microbiome?

M Van Hul, PD Cani, C Petitfils, WM De Vos, H Tilg… - Gut, 2024 - gut.bmj.com
The understanding that changes in microbiome composition can influence chronic human
diseases and the efficiency of therapies has driven efforts to develop microbiota-centred …

Desulfovibrio vulgaris, a potent acetic acid-producing bacterium, attenuates nonalcoholic fatty liver disease in mice

Y Hong, L Sheng, J Zhong, X Tao, W Zhu, J Ma… - Gut …, 2021 - Taylor & Francis
The emerging evidence supports the use of prebiotics like herb-derived polysaccharides for
treating nonalcoholic fatty liver disease (NAFLD) by modulating gut microbiome. The present …

Pu-erh tea ameliorates obesity and modulates gut microbiota in high fat diet fed mice

J Ye, Y Zhao, X Chen, H Zhou, Y Yang, X Zhang… - Food Research …, 2021 - Elsevier
Obesity is regarded to be associated with fat accumulation, chronic inflammation, and gut
microbiota dysbiosis. Raw and ripened pu-erh tea extract (PETe) have the effect of reducing …