Bacterial persisters: molecular mechanisms and therapeutic development

H Niu, J Gu, Y Zhang - Signal transduction and targeted therapy, 2024 - nature.com
Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …

Tolerance and Resistance of Pseudomonas aeruginosa Biofilms to Antimicrobial Agents—How P. aeruginosa Can Escape Antibiotics

O Ciofu, T Tolker-Nielsen - Frontiers in microbiology, 2019 - frontiersin.org
Pseudomonas aeruginosa is one of the six bacterial pathogens, Enterococcus faecium,
Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas …

Recent updates on drug resistance in Mycobacterium tuberculosis

R Singh, SP Dwivedi, US Gaharwar… - Journal of applied …, 2020 - academic.oup.com
Tuberculosis (TB) along with acquired immune deficiency syndrome and malaria rank
among the top three fatal infectious diseases which pose threat to global public health …

Relationship between quorum sensing and secretion systems

RT Pena, L Blasco, A Ambroa… - Frontiers in …, 2019 - frontiersin.org
Quorum sensing (QS) is a communication mechanism between bacteria that allows specific
processes to be controlled, such as biofilm formation, virulence factor expression, production …

Mechanisms of antimicrobial resistance in biofilms

HY Liu, EL Prentice, MA Webber - npj Antimicrobials and Resistance, 2024 - nature.com
Most bacteria in nature exist in aggregated communities known as biofilms, and cells within
a biofilm demonstrate major physiological changes compared to their planktonic …

RpoS and the bacterial general stress response

S Bouillet, TS Bauer, S Gottesman - Microbiology and Molecular …, 2024 - journals.asm.org
The general stress response (GSR) is a widespread strategy developed by bacteria to adapt
and respond to their changing environments. The GSR is induced by one or multiple …

Intrinsic antimicrobial resistance: molecular biomaterials to combat microbial biofilms and bacterial persisters

S Barman, LB Kurnaz, R Leighton, MW Hossain… - Biomaterials, 2024 - Elsevier
The escalating rise in antimicrobial resistance (AMR) coupled with a declining arsenal of
new antibiotics is imposing serious threats to global public health. A pervasive aspect of …

The DNA damage inducible SOS response is a key player in the generation of bacterial persister cells and population wide tolerance

Z Podlesek, D Žgur Bertok - Frontiers in microbiology, 2020 - frontiersin.org
Population-wide tolerance and persisters enable susceptible bacterial cells to endure
hostile environments, including antimicrobial exposure. The SOS response can play a …

Mechanisms of drug-induced tolerance in Mycobacterium tuberculosis

SN Goossens, SL Sampson… - Clinical microbiology …, 2020 - journals.asm.org
Successful treatment of tuberculosis (TB) can be hampered by Mycobacterium tuberculosis
populations that are temporarily able to survive antibiotic pressure in the absence of drug …

Strategies to combat multidrug-resistant and persistent infectious diseases

O Pacios, L Blasco, I Bleriot, L Fernandez-Garcia… - Antibiotics, 2020 - mdpi.com
Antibiotic failure is one of the most worrying health problems worldwide. We are currently
facing an international crisis with several problematic facets: new antibiotics are no longer …