Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
Abstract l-Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is involved in
the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp …
the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp …
Discovery of IDO1 inhibitors: from bench to bedside
Small-molecule inhibitors of indoleamine 2, 3-dioxygenase-1 (IDO1) are emerging at the
vanguard of experimental agents in oncology. Here, pioneers of this new drug class provide …
vanguard of experimental agents in oncology. Here, pioneers of this new drug class provide …
Indoleamine 2, 3-dioxygenase and its therapeutic inhibition in cancer
The tryptophan catabolic enzyme indoleamine 2, 3-dioxygenase-1 (IDO1) has attracted
enormous attention in driving cancer immunosuppression, neovascularization, and …
enormous attention in driving cancer immunosuppression, neovascularization, and …
[HTML][HTML] Role of IDO and TDO in cancers and related diseases and the therapeutic implications
Z Ye, L Yue, J Shi, M Shao, T Wu - Journal of Cancer, 2019 - ncbi.nlm.nih.gov
Kynurenine (Kyn) pathway is a significant metabolic pathway of tryptophan (Trp). The
metabolites of the Kyn pathway are closely correlated with numerous diseases. Two main …
metabolites of the Kyn pathway are closely correlated with numerous diseases. Two main …
Differential roles of IDO1 and IDO2 in T and B cell inflammatory immune responses
Indoleamine-2, 3-dioxygenase (IDO) 1 and IDO2 are two closely related tryptophan
catabolizing enzymes encoded by linked genes. The IDO pathway is also …
catabolizing enzymes encoded by linked genes. The IDO pathway is also …
The kynurenine pathway—new linkage between innate and adaptive immunity in autoimmune endocrinopathies
A Krupa, I Kowalska - International Journal of Molecular Sciences, 2021 - mdpi.com
The kynurenine pathway (KP) is highly regulated in the immune system, where it promotes
immunosuppression in response to infection or inflammation. Indoleamine 2, 3-dioxygenase …
immunosuppression in response to infection or inflammation. Indoleamine 2, 3-dioxygenase …
Circulating pro-and anti-inflammatory metabolites and its potential role in rheumatoid arthritis pathogenesis
R Coras, JD Murillo-Saich, M Guma - Cells, 2020 - mdpi.com
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial
joints, leading to inflammation, joint destruction, loss of function, and disability. Although …
joints, leading to inflammation, joint destruction, loss of function, and disability. Although …
Intestinal dysbiosis and tryptophan metabolism in autoimmunity
J Brown, B Robusto, L Morel - Frontiers in immunology, 2020 - frontiersin.org
The development of autoimmunity involves complex interactions between genetics and
environmental triggers. The gut microbiota is an important environmental constituent that …
environmental triggers. The gut microbiota is an important environmental constituent that …
The kynurenine pathway as a novel link between allergy and the gut microbiome
AP Van der Leek, Y Yanishevsky… - Frontiers in …, 2017 - frontiersin.org
In the past few decades, the indoleamine 2, 3 dioxygenase (IDO) subset of the kynurenine
(KYN) pathway of tryptophan (TRP) metabolism has been the subject of much research in …
(KYN) pathway of tryptophan (TRP) metabolism has been the subject of much research in …
[HTML][HTML] Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?
A model of the development and progression of chronic fatigue syndrome (myalgic
encephalomyelitis), the aetiology of which is currently unknown, is put forward, starting with …
encephalomyelitis), the aetiology of which is currently unknown, is put forward, starting with …