Physical properties of blood and their relationship to clinical conditions
It has been long known that blood health heavily influences optimal physiological function.
Abnormalities affecting the physical properties of blood have been implicated in the …
Abnormalities affecting the physical properties of blood have been implicated in the …
Increased blood viscosity and red blood cell aggregation in patients with COVID‐19
E Nader, C Nougier, C Boisson… - American journal of …, 2022 - Wiley Online Library
The aim of this study was to (1) analyze blood viscosity, red blood cell (RBC) deformability,
and aggregation in hospitalized patients with Coronavirus disease 19 (COVID‐19);(2) test …
and aggregation in hospitalized patients with Coronavirus disease 19 (COVID‐19);(2) test …
[HTML][HTML] Blood clot contraction: mechanisms, pathophysiology, and disease
A State of the Art lecture titled “Blood Clot Contraction: Mechanisms, Pathophysiology, and
Disease” was presented at the International Society on Thrombosis and Haemostasis (ISTH) …
Disease” was presented at the International Society on Thrombosis and Haemostasis (ISTH) …
Clot retraction: cellular mechanisms and inhibitors, measuring methods, and clinical implications
EE Jansen, M Hartmann - Biomedicines, 2021 - mdpi.com
Platelets have important functions in hemostasis. Best investigated is the aggregation of
platelets for primary hemostasis and their role as the surface for coagulation leading to fibrin …
platelets for primary hemostasis and their role as the surface for coagulation leading to fibrin …
Combined computational modeling and experimental study of the biomechanical mechanisms of platelet-driven contraction of fibrin clots
C Michael, F Pancaldi, S Britton, OV Kim… - Communications …, 2023 - nature.com
While blood clot formation has been relatively well studied, little is known about the
mechanisms underlying the subsequent structural and mechanical clot remodeling called …
mechanisms underlying the subsequent structural and mechanical clot remodeling called …
Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease
EM Sparkenbaugh, MW Henderson, M Miller-Awe… - Blood, 2023 - ashpublications.org
A hypercoagulable state, chronic inflammation, and increased risk of venous thrombosis and
stroke are prominent features in patients with sickle cell disease (SCD). Coagulation factor …
stroke are prominent features in patients with sickle cell disease (SCD). Coagulation factor …
Extent of intravital contraction of arterial and venous thrombi and pulmonary emboli
Blood clots and thrombi undergo platelet-driven contraction/retraction followed by structural
rearrangements. We have established quantitative relationships between the composition of …
rearrangements. We have established quantitative relationships between the composition of …
[HTML][HTML] Activation of Piezo1 channels in compressed red blood cells augments platelet-driven contraction of blood clots
Background Piezo1 is a mechanosensitive cationic channel that boosts intracellular [Ca 2+]
i. Compression of red blood cells (RBCs) during platelet-driven contraction of blood clots …
i. Compression of red blood cells (RBCs) during platelet-driven contraction of blood clots …
[HTML][HTML] Why platelet mechanotransduction matters for hemostasis and thrombosis
Mechanotransduction is the ability of cells to “feel” or sense their mechanical
microenvironment and integrate and convert these physical stimuli into adaptive …
microenvironment and integrate and convert these physical stimuli into adaptive …
Hyperelasticity of Blood Clots: Bridging the Gap between Microscopic and Continuum Scales
The biomechanical properties of blood clots, which are dictated by their compositions and
micro-structures, play a critical role in determining their fates, ie, occlusion, persistency, or …
micro-structures, play a critical role in determining their fates, ie, occlusion, persistency, or …