Hypertension affects a significant proportion of the adult and aging population and
represents an important risk factor for vascular cognitive impairment and late-life dementia …

Amyloid-ß (Aß) is best known as the misfolded peptide that is involved in the pathogenesis
of Alzheimer's disease (AD), and it is currently the primary therapeutic target in attempts to …

Flow of cerebrospinal fluid (CSF) through perivascular spaces (PVSs) in the brain is
important for clearance of metabolic waste. Arterial pulsations are thought to drive flow, but …

Importance The association between late-life blood pressure (BP) and cognition may
depend on the presence and chronicity of past hypertension. Late-life declines in blood …

Hypertension is a highly prevalent condition which has been established as a risk factor for
cardiovascular and cerebrovascular disease. Although the understanding of the relationship …

While prevailing evidence supports that the amyloid cascade hypothesis is a key component
of Alzheimer's disease (AD) pathology, many recent studies indicate that the vascular …

The brain is highly dependent on an adequate delivery of oxygen and glucose from the
circulation, and cerebral blood flow (CBF) reductions impair neuronal function and, if …

Essential hypertension has devastating effects on the brain, being the major cause of stroke
and a leading cause of dementia. Hypertension alters the structure of cerebral blood vessels …

Background: Hypertension is an established risk factor for stroke and vascular dementia but
recent meta-analyses examining the association between Alzheimer's disease (AD) and …

The incidence of dementia is increasing at an alarming rate, and has become a major public
health concern. Alzheimer disease (AD) is the most common form of dementia and is …