Interaction modules that impart specificity to disordered protein
Intrinsically disordered regions (IDRs) are especially enriched among proteins that regulate
chromatin and transcription. As a result, mechanisms that influence specificity of IDR-driven …
chromatin and transcription. As a result, mechanisms that influence specificity of IDR-driven …
What do transcription factors interact with?
Although we have made significant progress, we still possess a limited understanding of
how genomic and epigenomic information directs gene expression programs through …
how genomic and epigenomic information directs gene expression programs through …
Structural insights into preinitiation complex assembly on core promoters
INTRODUCTION RNA polymerase II (Pol II)–mediated transcription initiation requires
assembly of a preinitiation complex (PIC), during which the 14-subunit transcription factor IID …
assembly of a preinitiation complex (PIC), during which the 14-subunit transcription factor IID …
Tumor suppressor p53: from engaging DNA to target gene regulation
The p53 transcription factor confers its potent tumor suppressor functions primarily through
the regulation of a large network of target genes. The recent explosion of next generation …
the regulation of a large network of target genes. The recent explosion of next generation …
Inferring transcriptional bursting kinetics from single-cell snapshot data using a generalized telegraph model
Gene expression has inherent stochasticity resulting from transcription's burst manners.
Single-cell snapshot data can be exploited to rigorously infer transcriptional burst kinetics …
Single-cell snapshot data can be exploited to rigorously infer transcriptional burst kinetics …
Multiple direct interactions of TBP with the MYC oncoprotein
Transcription factor c-MYC is a potent oncoprotein; however, the mechanism of
transcriptional regulation via MYC-protein interactions remains poorly understood. The …
transcriptional regulation via MYC-protein interactions remains poorly understood. The …
What could go wrong? A practical guide to single-particle cryo-EM: from biochemistry to atomic models
Cryo-electron microscopy (cryo-EM) has enjoyed explosive recent growth due to
revolutionary advances in hardware and software, resulting in a steady stream of long …
revolutionary advances in hardware and software, resulting in a steady stream of long …
p53 pulse modulation differentially regulates target gene promoters to regulate cell fate decisions
The p53 tumor suppressor regulates distinct responses to cellular stresses. Although
different stresses generate different p53 dynamics, the mechanisms by which cells decode …
different stresses generate different p53 dynamics, the mechanisms by which cells decode …
[HTML][HTML] Transcriptional kinetic synergy: A complex landscape revealed by integrating modeling and synthetic biology
Transcription factors (TFs) control gene expression, often acting synergistically. Classical
thermodynamic models offer a biophysical explanation for synergy based on binding …
thermodynamic models offer a biophysical explanation for synergy based on binding …
Imaging organization of RNA processing within the nucleus
Within the nucleus, messenger RNA is generated and processed in a highly organized and
regulated manner. Messenger RNA processing begins during transcription initiation and …
regulated manner. Messenger RNA processing begins during transcription initiation and …