Hexokinases are a family of ubiquitous exose-phosphorylating enzymes that prime glucose
for intracellular utilization. Hexokinase 2 (HK2) is the most active isozyme of the family …

Cancer reprogramming is an important facilitator of cancer development and survival, with
tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation …

High expression of PD-L1 in tumor cells contributes to tumor immune evasion. However,
whether PD-L1 expression in tumor cells is regulated by the availability of nutrients is …

Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …

Cancer cells characterized by uncontrolled growth and proliferation require altered
metabolic processes to maintain this characteristic. Metabolic reprogramming is a process …

Background Hypoxia is a key feature of breast cancer, which affects cancer development,
metastasis and metabolism. Previous studies suggested that circular RNAs (circRNAs) could …

Tumor cells possess complex immune evasion mechanisms to evade immune system
attacks, primarily through metabolic reprogramming, which significantly alters the tumor …

Hepatocellular carcinoma (HCC) or hepatoma is malignant cancer that starts from the main
liver cells. Although various classical methods have been used for patients with HCC …

Metabolic alterations, a hallmark of cancer, enable tumor cells to adapt to their environment
by modulating glucose, lipid, and amino acid metabolism, which fuels rapid growth and …

Background Reprogrammed glucose metabolism of enhanced Warburg effect (or aerobic
glycolysis) is considered as a hallmark of cancer. Long non-coding RNAs (lncRNAs) have …