Nucleases cleave the phosphodiester bonds of nucleic acids and may be endo or exo,
DNase or RNase, topoisomerases, recombinases, ribozymes, or RNA splicing enzymes. In …

The multisubunit RNA exosome complex is a major ribonuclease of eukaryotic cells that
participates in the processing, quality control and degradation of virtually all classes of RNA …

Prokaryotic chromosomes code for toxin–antitoxin (TA) loci, often in multiple copies. In E.
coli, experimental evidence indicates that TA loci are stress-response elements that help …

Eukaryotic PIN (PilT N-terminal) domain proteins are ribonucleases involved in quality
control, metabolism and maturation of mRNA and rRNA. The majority of prokaryotic PIN …

Genes for toxin-antitoxin (TA) complexes are widespread in prokaryote genomes, and
species frequently possess tens of plasmid and chromosomal TA loci. The complexes are …

The exosome is a major eukaryotic nuclease located in both the nucleus and the cytoplasm
that contributes to the processing, quality control and/or turnover of a large number of …

The eukaryotic exosome is a ten-subunit 3′ exoribonucleolytic complex responsible for
many RNA-processing and RNA-degradation reactions. How the exosome accomplishes …

Toxin-antitoxin systems are very commonly found both on large, low-copy plasmids, where
they increase effective stability (35), and on bacterial chromosomes, where their function has …

Proper regulation of ribosome biosynthesis is mandatory for cellular adaptation, growth and
proliferation. Ribosome biogenesis is the most energetically demanding cellular process …

Bacterial genomes frequently contain operons that encode a toxin and its antidote. These
'toxin–antitoxin (TA) modules' have an important role in bacterial stress physiology and …