Malignant astrocytic glioma: genetics, biology, and paths to treatment
Malignant astrocytic gliomas such as glioblastoma are the most common and lethal
intracranial tumors. These cancers exhibit a relentless malignant progression characterized …
intracranial tumors. These cancers exhibit a relentless malignant progression characterized …
Glioblastoma multiforme: an overview of emerging therapeutic targets
OG Taylor, JS Brzozowski, KA Skelding - Frontiers in oncology, 2019 - frontiersin.org
Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain
tumour in humans and has a very poor prognosis. The existing treatments have had limited …
tumour in humans and has a very poor prognosis. The existing treatments have had limited …
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
Cancer Genome Atlas Research Network Tissue … - Nature, 2008 - nature.com
Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide
substitutions and epigenetic modifications that drive malignant transformation. The Cancer …
substitutions and epigenetic modifications that drive malignant transformation. The Cancer …
An integrated genomic analysis of human glioblastoma multiforme
Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To
identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes …
identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes …
Paediatric and adult glioblastoma: multiform (epi) genomic culprits emerge
We have extended our understanding of the molecular biology that underlies adult
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …
Emerging insights into the molecular and cellular basis of glioblastoma
GP Dunn, ML Rinne, J Wykosky… - Genes & …, 2012 - genesdev.cshlp.org
Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive
multiplatform genomic characterization has provided a higher-resolution picture of the …
multiplatform genomic characterization has provided a higher-resolution picture of the …
Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease
BS Paugh, C Qu, C Jones, Z Liu… - Journal of clinical …, 2010 - ascopubs.org
Purpose To define copy number alterations and gene expression signatures underlying
pediatric high-grade glioma (HGG). Patients and Methods We conducted a high-resolution …
pediatric high-grade glioma (HGG). Patients and Methods We conducted a high-resolution …
Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises
TA Yap, MD Garrett, MI Walton, F Raynaud… - Current opinion in …, 2008 - Elsevier
The strategy of 'drugging the cancer kinome'has led to the successful development and
regulatory approval of several novel molecular targeted agents. The spotlight is now shifting …
regulatory approval of several novel molecular targeted agents. The spotlight is now shifting …
Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities
Pediatric solid and central nervous system tumors are the leading cause of cancer-related
death among children. Identifying new targeted therapies necessitates the use of pediatric …
death among children. Identifying new targeted therapies necessitates the use of pediatric …
Recent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical development
H Zhao, J Wang, W Shao, C Wu, Z Chen, ST To, W Li - Molecular cancer, 2017 - Springer
Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary
tumor in the central nervous system. One of the most widely used chemotherapeutic drugs …
tumor in the central nervous system. One of the most widely used chemotherapeutic drugs …