Adenosine triphosphate (ATP) accumulates at sites of tissue injury and inflammation. Effects
of extracellular ATP are mediated by plasma membrane receptors named P2 receptors …

Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …

Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Seven P2X ion channel nucleotide receptor subtypes have been cloned and characterised.
P2X7 receptors (P2X7R) are unusual in that there are extra amino acids in the intracellular …

P2X7 is a transmembrane receptor expressed in multiple cell types including neurons,
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …

Scientists and health professionals are exhaustively trying to contain the coronavirus
disease 2019 (COVID-19) pandemic by elucidating viral invasion mechanisms, possible …

Diabetic nephropathy (DN), a sterile inflammatory disease, is a serious complication of
diabetes mellitus. However, recent evidence indicates that pyroptosis, a new term for pro …

The formation and accumulation of crystalline material in tissues is a hallmark of many
metabolic and inflammatory conditions. The discovery that the phase transition of …

Severe pneumonia which shares several of the features of acute respiratory distress
syndrome (ARDS) is the main cause of morbidity and mortality in Coronavirus disease 19 …

P2X7 receptor is an ion channel activated by extracellular adenosine trisphosphate (eATP)
that attracted increasing attention for its role in immune reactions, neurobiology and …