Chemical design and synthesis of functionalized probes for imaging and treating tumor hypoxia
Hypoxia development in tumor is closely associated with its increased aggressiveness and
strong resistance to therapy, leading to the poor prognosis in several cancer types …
strong resistance to therapy, leading to the poor prognosis in several cancer types …
Nanoenzyme-augmented cancer sonodynamic therapy by catalytic tumor oxygenation
P Zhu, Y Chen, J Shi - ACS nano, 2018 - ACS Publications
Ultrasound (US)-triggered sonodynamic therapy (SDT) can solve the critical issue of low
tissue-penetrating depth of traditional phototriggered therapies, but the SDT efficacy is still …
tissue-penetrating depth of traditional phototriggered therapies, but the SDT efficacy is still …
Intelligent Albumin-MnO2 Nanoparticles as pH-/H2 O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy.
A unique type of pH/H2 O2 dual-responsive intelligent nanoscale delivery system based on
albumin-coated MnO2 is presented, which is capable of modulating the tumor …
albumin-coated MnO2 is presented, which is capable of modulating the tumor …
Multifunctional Albumin–MnO2 Nanoparticles Modulate Solid Tumor Microenvironment by Attenuating Hypoxia, Acidosis, Vascular Endothelial Growth Factor and …
Insufficient oxygenation (hypoxia), acidic pH (acidosis), and elevated levels of reactive
oxygen species (ROS), such as H2O2, are characteristic abnormalities of the tumor …
oxygen species (ROS), such as H2O2, are characteristic abnormalities of the tumor …
Design of Hybrid MnO2‐Polymer‐Lipid Nanoparticles with Tunable Oxygen Generation Rates and Tumor Accumulation for Cancer Treatment
Manganese dioxide (MnO2) nanoparticles (NPs) were discovered in previous work to be
effective in improving tumor oxygenation (hypoxia) and reducing H2O2 and acidity in the …
effective in improving tumor oxygenation (hypoxia) and reducing H2O2 and acidity in the …