Interleukin-7 (IL-7), a molecule known for its growth-promoting effects on progenitors of B
cells, remains one of the most extensively studied cytokines. It plays a vital role in health …

Interleukin-2 receptor (IL-2R) signaling regulates tolerance and immunity. Here, we review
recent work concerning the structure, signaling, and function of the IL-2R, emphasizing the …

The peripheral mature T cell pool is regulated by complex homeostatic mechanisms. Naive
T cells are maintained by interleukin-7 (IL-7) and T cell receptor (TCR) signaling from …

Abstract Interleukin-7 (IL-7) is produced by stromal cells in lymphoid tissues and is required
for the development of T cells and for their persistence in the periphery. Unlike many other …

Abstract IL-2, IL-15, and IL-7 are cytokines that are critical for regulating lymphoid
homeostasis. These cytokines stimulate similar responses from lymphocytes in vitro, but play …

IL-7 is well known as a lymphopoietic cytokine, but recent studies have also identified a
critical role for IL-7 in peripheral T cell homeostasis. IL-7 is well poised to serve as a …

All hematopoietic cells, including T lymphocytes, originate from stem cells that reside in the
bone marrow. Most hematopoietic lineages also mature in the bone marrow, but in this …

IL-7 is essential for the development and survival of T lymphocytes. This review is primarily
from the perspective of the cell biology of the responding T cell. Beginning with IL-7 receptor …

Members of the Runx family of transcriptional regulators are required for the appropriate
expression of CD4 and CD8 at discrete stages of T cell development. The roles of these …

Like all hematopoietic cells, T lymphocytes are derived from bone-marrow-resident stem
cells. However, whereas most blood lineages are generated within the marrow, the majority …