IL-6 and IL-8: an overview of their roles in healthy and pathological pregnancies
A Vilotić, M Nacka-Aleksić, A Pirković… - International journal of …, 2022 - mdpi.com
Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action,
mediating innate and adaptive immunity and multiple physiological processes, including …
mediating innate and adaptive immunity and multiple physiological processes, including …
Inflammasomes: their role in normal and complicated pregnancies
Inflammasomes are cytoplasmic multiprotein complexes that coordinate inflammatory
responses, including those that take place during pregnancy. Inflammasomes and their …
responses, including those that take place during pregnancy. Inflammasomes and their …
Single cell transcriptional signatures of the human placenta in term and preterm parturition
More than 135 million births occur each year; yet, the molecular underpinnings of human
parturition in gestational tissues, and in particular the placenta, are still poorly understood …
parturition in gestational tissues, and in particular the placenta, are still poorly understood …
[HTML][HTML] Clinical chorioamnionitis at term I: microbiology of the amniotic cavity using cultivation and molecular techniques
Introduction: The objectives of this study were: 1) to determine the amniotic fluid (AF)
microbiology of patients with the diagnosis of clinical chorioamnionitis at term using both …
microbiology of patients with the diagnosis of clinical chorioamnionitis at term using both …
[HTML][HTML] A single-cell atlas of the myometrium in human parturition
Parturition is a well-orchestrated process characterized by increased uterine contractility,
cervical ripening, and activation of the chorioamniotic membranes; yet, the transition from a …
cervical ripening, and activation of the chorioamniotic membranes; yet, the transition from a …
Sterile intra-amniotic inflammation in asymptomatic patients with a sonographic short cervix: prevalence and clinical significance
Objective: To determine the frequency and clinical significance of sterile and microbial-
associated intra-amniotic inflammation in asymptomatic patients with a sonographic short …
associated intra-amniotic inflammation in asymptomatic patients with a sonographic short …
Damage-associated molecular patterns (DAMPs) in preterm labor with intact membranes and preterm PROM: a study of the alarmin HMGB1
Objective. Preterm parturition is a syndrome caused by multiple etiologies. Although intra-
amniotic infection is causally linked with intrauterine inflammation and the onset of preterm …
amniotic infection is causally linked with intrauterine inflammation and the onset of preterm …
Uterine overdistention induces preterm labor mediated by inflammation: observations in pregnant women and nonhuman primates
Objective Uterine overdistention is thought to induce preterm labor in women with twin and
multiple pregnancies, but the pathophysiology remains unclear. We investigated for the first …
multiple pregnancies, but the pathophysiology remains unclear. We investigated for the first …
Progesterone receptor-A and-B have opposite effects on proinflammatory gene expression in human myometrial cells: implications for progesterone actions in human …
Context: Progesterone promotes uterine relaxation during pregnancy and its withdrawal
induces labor. Progesterone withdrawal in human parturition is mediated in part by changes …
induces labor. Progesterone withdrawal in human parturition is mediated in part by changes …
Physiologic uterine inflammation and labor onset: integration of endocrine and mechanical signals
O Shynlova, YH Lee, K Srikhajon… - Reproductive …, 2013 - journals.sagepub.com
The mechanisms underlying the preparation of the uterus for labor are not fully understood.
Our previous studies have shown that during pregnancy, the uterine muscle (myometrium) …
Our previous studies have shown that during pregnancy, the uterine muscle (myometrium) …