Using single-vesicle technologies to unravel the heterogeneity of extracellular vesicles

G Bordanaba-Florit, F Royo, SG Kruglik… - Nature …, 2021 - nature.com
Extracellular vesicles (EVs) are heterogeneous lipid containers with a complex molecular
cargo comprising several populations with unique roles in biological processes. These …

Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: Strategies and significance

S Salunkhe, M Basak, D Chitkara, A Mittal - Journal of Controlled …, 2020 - Elsevier
Exosomes are natural nanovesicles excreted by many cells for intercellular communication
and for transfer of materials including proteins, nucleic acids and even synthetic therapeutic …

Exosome theranostics: biology and translational medicine

C He, S Zheng, Y Luo, B Wang - Theranostics, 2018 - pmc.ncbi.nlm.nih.gov
Exosomes are common membrane-bound nanovesicles that contain diverse biomolecules,
such as lipids, proteins, and nucleic acids. Exosomes are derived from cells through …

Extracellular vesicles: unique intercellular delivery vehicles

SLN Maas, XO Breakefield, AM Weaver - Trends in cell biology, 2017 - cell.com
Extracellular vesicles (EVs) are a heterogeneous collection of membrane-bound carriers
with complex cargoes including proteins, lipids, and nucleic acids. While the release of EVs …

Extracellular vesicles as biomarkers and therapeutic tools: from pre-clinical to clinical applications

MC Ciferri, R Quarto, R Tasso - Biology, 2021 - mdpi.com
Simple Summary Extracellular vesicles (EVs) are membrane-bound vesicles released by all
cell types, differing in biogenesis, physical characteristics, and contents. Due to their central …

Engineering hybrid exosomes by membrane fusion with liposomes

YT Sato, K Umezaki, S Sawada, S Mukai, Y Sasaki… - Scientific reports, 2016 - nature.com
Exosomes are a valuable biomaterial for the development of novel nanocarriers as
functionally advanced drug delivery systems. To control and modify the performance of …

High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources

RA Haraszti, MC Didiot, E Sapp, J Leszyk… - Journal of …, 2016 - Taylor & Francis
Extracellular vesicles (EVs), including exosomes and microvesicles (MVs), are explored for
use in diagnostics, therapeutics and drug delivery. However, little is known about the …

Integrated isolation and quantitative analysis of exosome shuttled proteins and nucleic acids using immunocapture approaches

N Zarovni, A Corrado, P Guazzi, D Zocco, E Lari… - Methods, 2015 - Elsevier
Clinical implementation of exosome based diagnostic and therapeutic applications is still
limited by the lack of standardized technologies that integrate efficient isolation of exosomes …

A comprehensive overview of exosomes as drug delivery vehicles—endogenous nanocarriers for targeted cancer therapy

KB Johnsen, JM Gudbergsson, MN Skov… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Exosomes denote a class of secreted nanoparticles defined by size, surface protein and
lipid composition, and the ability to carry RNA and proteins. They are important mediators of …

Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets

G Szabo, F Momen-Heravi - Nature reviews Gastroenterology & …, 2017 - nature.com
Extracellular vesicles (EVs) are membranous vesicles originating from different cells in the
liver. The pathophysiological role of EVs is increasingly recognized in liver diseases …