Targeting the tumour vasculature: from vessel destruction to promotion

S Guelfi, K Hodivala-Dilke, G Bergers - Nature Reviews Cancer, 2024 - nature.com
As angiogenesis was recognized as a core hallmark of cancer growth and survival, several
strategies have been implemented to target the tumour vasculature. Yet to date, attempts …

Updates on systemic therapy for hepatocellular carcinoma

P Ntellas, I Chau - American Society of Clinical Oncology Educational …, 2024 - ascopubs.org
This review explores the dynamic landscape of hepatocellular carcinoma (HCC) treatment,
emphasizing on recent developments across various stages and therapeutic approaches …

Adjuvant sintilimab in resected high-risk hepatocellular carcinoma: a randomized, controlled, phase 2 trial

K Wang, YJ **ang, HM Yu, YQ Cheng, ZH Liu, YY Qin… - Nature Medicine, 2024 - nature.com
Hepatocellular carcinoma (HCC), particularly when accompanied by microvascular invasion
(MVI), has a markedly high risk of recurrence after liver resection. Adjuvant immunotherapy …

Adjuvant and neoadjuvant immunotherapies in hepatocellular carcinoma

JM Llovet, R Pinyol, M Yarchoan, AG Singal… - Nature Reviews …, 2024 - nature.com
Liver cancer, specifically hepatocellular carcinoma (HCC), is the sixth most common cancer
and the third leading cause of cancer mortality worldwide. The development of effective …

Immunotherapy at all stages of hepatocellular carcinoma

DJ Pinato, CAM Fulgenzi, A D'Alessio - Nature Medicine, 2024 - nature.com
A flurry of emerging treatment options is transforming the therapeutic landscape of
hepatocellular carcinoma; two new studies highlight the complexities and gaps in …

APASL clinical practice guidelines on systemic therapy for hepatocellular carcinoma-2024

G Lau, S Obi, J Zhou, R Tateishi, S Qin, H Zhao… - Hepatology …, 2024 - Springer
Abstract In Asia–Pacific region, hepatocellular carcinoma is a serious health threat
attributing to over 600,000 deaths each year and account for over 70% of global cases …

Tumor microenvironment composition and related therapy in hepatocellular carcinoma

Z Li, Z Zhang, L Fang, J Zhao, Z Niu… - Journal of …, 2023 - Taylor & Francis
Globally, primary liver cancer is the third leading cause of cancer death, and hepatocellular
carcinoma (HCC) accounts for 75%–95%. The tumor microenvironment (TME), composed of …

[HTML][HTML] The treatment of hepatocellular carcinoma with major vascular invasion

T Tadokoro, J Tani, A Morishita, K Fujita, T Masaki… - Cancers, 2024 - mdpi.com
Simple Summary Hepatocellular carcinoma with vascular invasion has a poor prognosis
and inconsistent treatment evidence. Studies of portal vein tumor thrombus are relatively …

Histological predictors of aggressive recurrence of hepatocellular carcinoma after liver resection

C Fuster-Anglada, E Mauro, J Ferrer-Fàbrega… - Journal of …, 2024 - Elsevier
Background & Aims Assessment of recurrence risk after liver resection (LR) is critical in
hepatocellular carcinoma (HCC), particularly with the advent of effective adjuvant therapy …

Merits and boundaries of the Barcelona Clinic Liver Cancer Staging and Treatment Algorithm: learning from the past to improve the future with a novel proposal.

F Trevisani, A Vitale, M Kudo, L Kulik, JW Park… - Journal of …, 2024 - Elsevier
Summary This Expert Opinion article thoroughly analyses the Barcelona Clinic Liver Cancer
(BCLC) staging and treatment algorithm for hepatocellular carcinoma (HCC) that, since …