Vascular smooth muscle (VSM) plays an important role in the regulation of vascular function.
Identifying the mechanisms of VSM contraction has been a major research goal in order to …

PKC (protein kinase C) has been in the limelight since the discovery three decades ago that
it acts as a major receptor for the tumour-promoting phorbol esters. Phorbol esters, with their …

The epithelial-mesenchymal transition program becomes activated during malignant
progression and can enrich for cancer stem cells (CSCs). We report that inhibition of protein …

The complex mTORC2 is accepted to be the kinase that controls the phosphorylation of the
hydrophobic motif, a key regulatory switch for AGC kinases, although whether mTOR directly …

The maturing mutational landscape of cancer genomes, the development and application of
clinical interventions and evolving insights into tumour-associated functions reveal …

Basal-like breast cancers are an aggressive breast cancer subtype, which often lack
estrogen receptor, progesterone receptor, and Her2 expression, and are resistant to …

Protein kinase C (PKC) isozymes function as tumor suppressors in increasing contexts. In
contrast to oncogenic kinases, whose function is acutely regulated by transient …

Optimal tuning of enzyme signaling is critical for cellular homeostasis. We use fluorescence
resonance energy transfer reporters in live cells to follow conformational transitions that tune …

Abstract Protein Kinase C (PKC) isozymes are tightly regulated kinases that transduce a
myriad of signals from receptor-mediated hydrolysis of membrane phospholipids. They play …

The signaling output of protein kinase C (PKC) is exquisitely controlled, with its disruption
resulting in pathophysiologies. Identifying the structural basis for autoinhibition is central to …