▪ Abstract Hemoglobin degradation in intraerythrocytic malaria parasites is a vast process
that occurs in an acidic digestive vacuole. Proteases that participate in this catabolic …

Abstract Interpretation of the new information arising from the Plasmodium falciparum
Genome Project requires a good working knowledge of the ultrastructure of the parasite; …

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells,
in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient …

Increased tolerance of Plasmodium falciparum to front-line artemisinin antimalarials (ARTs)
is associated with mutations in Kelch13 (K13), although the precise role of K13 remains …

The malaria parasite Plasmodium falciparum uses host erythrocyte hemoglobin as a major
nutrient source. We report the purification of P. falciparum digestive vacuoles and …

The 4-aminoquinoline chloroquine (1) can be considered to be one of the most important
synthetic chemotherapeutic agents in history. Since its discovery, chloroquine has proved to …

Chemical analysis has shown that Plasmodium falciparum trophozoites contain 61+/-2% of
the iron within parasitized erythrocytes, of which 92+/-6% is located within the food vacuole …

The human malaria parasite, Plasmodium falciparum, degrades nearly all its host cell
hemoglobin during a short segment of its intraerythrocytic development. This massive …

To ensure their survival in the human bloodstream, malaria parasites degrade up to 80% of
the host erythrocyte hemoglobin in an acidified digestive vacuole. Here, we combine …

The mitochondrion of Plasmodium species is a validated drug target. However, very little is
known about the functions of this organelle. In this review, we utilize data available from the …