Novel therapies for the treatment of cardiac fibrosis following myocardial infarction

K Raziyeva, Y Kim, Z Zharkinbekov, K Temirkhanova… - Biomedicines, 2022 - mdpi.com
Cardiac fibrosis is a common pathological consequence of most myocardial diseases. It is
associated with the excessive accumulation of extracellular matrix proteins as well as …

Preclinical large animal Porcine models for Cardiac Regeneration and its clinical translation: role of hiPSC-Derived cardiomyocytes

D Sridharan, N Pracha, SJ Rana, S Ahmed, AJ Dewani… - Cells, 2023 - mdpi.com
Myocardial Infarction (MI) occurs due to a blockage in the coronary artery resulting in
ischemia and necrosis of cardiomyocytes in the left ventricular heart muscle. The dying …

Ionizable lipid nanoparticle-mediated delivery of plasmid DNA in cardiomyocytes

S Scalzo, AK Santos, HAS Ferreira… - International Journal …, 2022 - Taylor & Francis
Introduction Gene therapy is a promising approach to be applied in cardiac regeneration
after myocardial infarction and gene correction for inherited cardiomyopathies. However …

High‐yield nanovesicles extruded from dental follicle stem cells promote the regeneration of periodontal tissues as an alternative of exosomes

L Liang, L Wang, Z Liao, L Ma, P Wang… - Journal of Clinical …, 2024 - Wiley Online Library
Aim To identify an optimized strategy for the large‐scale production of nanovesicles (NVs)
that preserve the biological properties of exosomes (EXOs) for use in periodontal …

[HTML][HTML] Progress and prospects of gene therapy in ophthalmology from 2000 to 2022: A bibliometric analysis

B Li, W Tan, Z Wang, H Zhou, J Zou, Y Li, S Yoshida… - Heliyon, 2023 - cell.com
Background Gene therapy is a treatment approach at the genetic level, which brings great
advances in many diseases and develops rapidly in recent years. Currently, its mechanism …

The angiogenic balance and its implications in cancer and cardiovascular diseases: An overview

C Ionescu, B Oprea, G Ciobanu, M Georgescu, R Bică… - Medicina, 2022 - mdpi.com
Angiogenesis is the process of develo** new blood vessels from pre-existing ones. This
review summarizes the main features of physiological and pathological angiogenesis and …

Heart immunoengineering by lentiviral vector-mediated genetic modification during normothermic ex vivo perfusion

K Schmalkuche, T Rother, JM Burgmann… - Frontiers in …, 2024 - frontiersin.org
Heart transplantation is associated with major hurdles, including the limited number of
available organs for transplantation, the risk of rejection due to genetic discrepancies, and …

Gene therapy for cardiomyocyte renewal: cell cycle, a potential therapeutic target

Y Son, W Zhu - Molecular diagnosis & therapy, 2023 - Springer
Heart disease is the primary cause of death worldwide. Even though extensive research has
been done, and many pharmacological and surgical treatments have been introduced to …

The Long and Winding Road to Cardiac Regeneration

AM Sacco, C Castaldo, F Di Meglio, D Nurzynska… - Applied Sciences, 2023 - mdpi.com
Cardiac regeneration is a critical endeavor in the treatment of heart diseases, aimed at
repairing and enhancing the structure and function of damaged myocardium. This review …

[HTML][HTML] Genetics in the diagnosis and treatment of cardiovascular diseases

K Bliden, S Singh, R Shanoada, I Kalia… - Journal of …, 2024 - oaepublish.com
Cardiovascular diseases (CVDs) remain one of the leading causes of morbidity and
mortality worldwide, with genetics being a major risk factor. Genetic cardiovascular disease …