Professional phagocytes (polymorphonuclear neutrophils and monocytes/macrophages) are
a main component of the immune system. These cells are involved in both host defenses …

With nearly one-third of the global population infected by Mycobacterium tuberculosis, TB
remains a major cause of death (1.7 million in 2006). TB is particularly severe in parts of …

Tuberculosis (TB) has troubled mankind for millennia, but current treatment strategies are
long and complicated and the disease remains a major global health problem. The risk of …

The complement system orchestrates a multi-faceted immune response to the invading
pathogen, Mycobacterium tuberculosis. Macrophages engulf the mycobacterial bacilli …

It has been shown that some antibiotics can modify cytokine production. We have examined
the effect of rifampicin on secretion of interleukin-1beta (IL-1β), IL-6, IL-10, and tumor …

Antibiotics directly inhibit the growth and kill microorganisms, and many of them have
immunomodulatory properties. We investigated the influence of cefotaxime and gentamicin …

Objective. Recently, it has become apparent that rifampin can act on eukaryotic cells
modulating production of host mediators. We aimed to study the cytoprotective effect of …

Pleural macrophages play critical roles in pathogenesis of tuberculous pleuritis, but very
little is known about their response to anti-tuberculosis antibiotics treatment. Here, we …

The antibiotic rifampicin is used extensively in the treatment of mycobacterial and other
infections. It has previously been suggested that rifampicin binds to and activates the …

Sepsis is a leading cause of death worldwide, despite the use of multimodal therapies.
Common antibiotic regimens are being affected by a rising number of multidrug-resistant …