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Calpain research for drug discovery: challenges and potential
Calpains are a family of proteases that were scientifically recognized earlier than
proteasomes and caspases, but remain enigmatic. However, they are known to participate in …
proteasomes and caspases, but remain enigmatic. However, they are known to participate in …
A sticky situation: When trypanosomatids attach to insect tissues
Transmission of trypanosomatids to their mammalian hosts requires a complex series of
developmental transitions in their insect vectors, including stable attachment to an insect …
developmental transitions in their insect vectors, including stable attachment to an insect …
An update on the knowledge of parasite–vector interactions of chagas disease
GA Schaub - Research and reports in tropical medicine, 2021 - Taylor & Francis
This review focusses on the interactions between the etiologic agent of Chagas disease,
Trypanosoma cruzi, and its triatomine vector. The flagellate mainly colonizes the intestinal …
Trypanosoma cruzi, and its triatomine vector. The flagellate mainly colonizes the intestinal …
Single-cell RNA sequencing of Trypanosoma brucei from tsetse salivary glands unveils metacyclogenesis and identifies potential transmission blocking antigens
A Vigneron, MB O'Neill, BL Weiss, AF Savage… - Proceedings of the …, 2020 - pnas.org
Tsetse-transmitted African trypanosomes must develop into mammalian-infectious
metacyclic cells in the fly's salivary glands (SGs) before transmission to a new host. The …
metacyclic cells in the fly's salivary glands (SGs) before transmission to a new host. The …
[HTML][HTML] Metacyclogenesis as the Starting Point of Chagas Disease
AZL Ferreira, CN de Araújo, ICC Cardoso… - International Journal of …, 2023 - mdpi.com
Chagas disease is a neglected infectious disease caused by the protozoan Trypanosoma
cruzi, primarily transmitted by triatomine vectors, and it threatens approximately seventy-five …
cruzi, primarily transmitted by triatomine vectors, and it threatens approximately seventy-five …
Triatomine physiology in the context of trypanosome infection
Triatomines are hematophagous insects that feed on the blood of vertebrates from different
taxa, but can occasionally also take fluids from invertebrate hosts, including other insects …
taxa, but can occasionally also take fluids from invertebrate hosts, including other insects …
Interaction of triatomines with their bacterial microbiota and trypanosomes
AA Guarneri, GA Schaub - Triatominae-The Biology of Chagas Disease …, 2021 - Springer
In this book chapter, we discuss the interactions between triatomines, two heteroxenous
trypanosomatids—Trypanosoma cruzi, the etiologic agent of Chagas disease, and …
trypanosomatids—Trypanosoma cruzi, the etiologic agent of Chagas disease, and …
[HTML][HTML] Comparison of potato and Asian citrus psyllid adult and nymph transcriptomes identified vector transcripts with potential involvement in circulative …
TW Fisher, M Vyas, R He, W Nelson, JM Cicero… - Pathogens, 2014 - mdpi.com
The potato psyllid (PoP) Bactericera cockerelli (Sulc) and Asian citrus psyllid (ACP)
Diaphorina citri Kuwayama are the insect vectors of the fastidious plant pathogen …
Diaphorina citri Kuwayama are the insect vectors of the fastidious plant pathogen …
Update on relevant trypanosome peptidases: Validated targets and future challenges
VE Alvarez, PA Iribarren, GT Niemirowicz… - Biochimica et Biophysica …, 2021 - Elsevier
Trypanosoma cruzi, the agent of the American Trypanosomiasis, Chagas disease, and
Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, the agents of …
Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, the agents of …
The Calpain Inhibitor MDL28170 Induces the Expression of Apoptotic Markers in Leishmania amazonensis Promastigotes
FA Marinho, KCS Gonçalves, SSC Oliveira… - PLoS …, 2014 - journals.plos.org
Background Human cutaneous leishmaniasis is caused by distinct species, including
Leishmania amazonensis. Treatment of cutaneous leishmaniasis is far from satisfactory due …
Leishmania amazonensis. Treatment of cutaneous leishmaniasis is far from satisfactory due …