Calpain research for drug discovery: challenges and potential

Y Ono, TC Saido, H Sorimachi - Nature Reviews Drug Discovery, 2016 - nature.com
Calpains are a family of proteases that were scientifically recognized earlier than
proteasomes and caspases, but remain enigmatic. However, they are known to participate in …

A sticky situation: When trypanosomatids attach to insect tissues

ML Povelones, NA Holmes, M Povelones - PLoS Pathogens, 2023 - journals.plos.org
Transmission of trypanosomatids to their mammalian hosts requires a complex series of
developmental transitions in their insect vectors, including stable attachment to an insect …

An update on the knowledge of parasite–vector interactions of chagas disease

GA Schaub - Research and reports in tropical medicine, 2021 - Taylor & Francis
This review focusses on the interactions between the etiologic agent of Chagas disease,
Trypanosoma cruzi, and its triatomine vector. The flagellate mainly colonizes the intestinal …

Single-cell RNA sequencing of Trypanosoma brucei from tsetse salivary glands unveils metacyclogenesis and identifies potential transmission blocking antigens

A Vigneron, MB O'Neill, BL Weiss, AF Savage… - Proceedings of the …, 2020 - pnas.org
Tsetse-transmitted African trypanosomes must develop into mammalian-infectious
metacyclic cells in the fly's salivary glands (SGs) before transmission to a new host. The …

[HTML][HTML] Metacyclogenesis as the Starting Point of Chagas Disease

AZL Ferreira, CN de Araújo, ICC Cardoso… - International Journal of …, 2023 - mdpi.com
Chagas disease is a neglected infectious disease caused by the protozoan Trypanosoma
cruzi, primarily transmitted by triatomine vectors, and it threatens approximately seventy-five …

Triatomine physiology in the context of trypanosome infection

AA Guarneri, MG Lorenzo - Journal of Insect Physiology, 2017 - Elsevier
Triatomines are hematophagous insects that feed on the blood of vertebrates from different
taxa, but can occasionally also take fluids from invertebrate hosts, including other insects …

Interaction of triatomines with their bacterial microbiota and trypanosomes

AA Guarneri, GA Schaub - Triatominae-The Biology of Chagas Disease …, 2021 - Springer
In this book chapter, we discuss the interactions between triatomines, two heteroxenous
trypanosomatids—Trypanosoma cruzi, the etiologic agent of Chagas disease, and …

[HTML][HTML] Comparison of potato and Asian citrus psyllid adult and nymph transcriptomes identified vector transcripts with potential involvement in circulative …

TW Fisher, M Vyas, R He, W Nelson, JM Cicero… - Pathogens, 2014 - mdpi.com
The potato psyllid (PoP) Bactericera cockerelli (Sulc) and Asian citrus psyllid (ACP)
Diaphorina citri Kuwayama are the insect vectors of the fastidious plant pathogen …

Update on relevant trypanosome peptidases: Validated targets and future challenges

VE Alvarez, PA Iribarren, GT Niemirowicz… - Biochimica et Biophysica …, 2021 - Elsevier
Trypanosoma cruzi, the agent of the American Trypanosomiasis, Chagas disease, and
Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, the agents of …

The Calpain Inhibitor MDL28170 Induces the Expression of Apoptotic Markers in Leishmania amazonensis Promastigotes

FA Marinho, KCS Gonçalves, SSC Oliveira… - PLoS …, 2014 - journals.plos.org
Background Human cutaneous leishmaniasis is caused by distinct species, including
Leishmania amazonensis. Treatment of cutaneous leishmaniasis is far from satisfactory due …