Inflammation and cardiovascular diseases: lessons from seminal clinical trials
Inflammation has been long regarded as a key contributor to atherosclerosis. Inflammatory
cells and soluble mediators play critical roles throughout arterial plaque development and …
cells and soluble mediators play critical roles throughout arterial plaque development and …
Lysoglycerophospholipids in chronic inflammatory disorders: the PLA2/LPC and ATX/LPA axes
I Sevastou, E Kaffe, MA Mouratis, V Aidinis - Biochimica et Biophysica Acta …, 2013 - Elsevier
Lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), the most prominent
lysoglycerophospholipids, are emerging as a novel class of inflammatory lipids, joining …
lysoglycerophospholipids, are emerging as a novel class of inflammatory lipids, joining …
Alveolar epithelial cells mitigate neutrophilic inflammation in lung injury through regulating mitochondrial fatty acid oxidation
KP Chung, CN Cheng, YJ Chen, CL Hsu… - Nature …, 2024 - nature.com
Abstract Type 2 alveolar epithelial (AT2) cells of the lung are fundamental in regulating
alveolar inflammation in response to injury. Impaired mitochondrial long-chain fatty acid β …
alveolar inflammation in response to injury. Impaired mitochondrial long-chain fatty acid β …
Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist
LJ Cohen, HS Kang, J Chu… - Proceedings of the …, 2015 - National Acad Sciences
The trillions of bacteria that make up the human microbiome are believed to encode
functions that are important to human health; however, little is known about the specific …
functions that are important to human health; however, little is known about the specific …
Novel lysophosphoplipid receptors: their structure and function
K Makide, A Uwamizu, Y Shinjo, J Ishiguro… - Journal of lipid …, 2014 - ASBMB
It is now accepted that lysophospholipids (LysoGPs) have a wide variety of functions as lipid
mediators that are exerted through G protein-coupled receptors (GPCRs) specific to each …
mediators that are exerted through G protein-coupled receptors (GPCRs) specific to each …
Novel bioactive glycerol-based lysophospholipids: new data–new insight into their function
A Grzelczyk, E Gendaszewska-Darmach - Biochimie, 2013 - Elsevier
Based on the results of research conducted over last two decades, lysophospholipids (LPLs)
were observed to be not only structural components of cellular membranes but also …
were observed to be not only structural components of cellular membranes but also …
Proton-sensing GPCRs in health and disease
The group of proton-sensing G-protein coupled receptors (GPCRs) consists of the four
receptors GPR4, TDAG8 (GPR65), OGR1 (GPR68), and G2A (GPR132). These receptors …
receptors GPR4, TDAG8 (GPR65), OGR1 (GPR68), and G2A (GPR132). These receptors …
Emerging roles for lysophosphatidylserine in resolution of inflammation
SC Frasch, DL Bratton - Progress in lipid research, 2012 - Elsevier
Despite overlap** structural aspects with other phospholipids, lysophosphatidylserine
(lysoPS), the monoacyl derivative of phosphatidylserine (diacylPS), appears to exert unique …
(lysoPS), the monoacyl derivative of phosphatidylserine (diacylPS), appears to exert unique …
Is microglial apoptosis an early pathogenic change in cerebral X‐linked adrenoleukodystrophy?
FS Eichler, JQ Ren, M Cossoy… - Annals of Neurology …, 2008 - Wiley Online Library
Objective Mutations in the X‐linked adrenoleukodystrophy (X‐ALD) protein cause
accumulation of unbranched saturated very‐long‐chain fatty acids, particularly in brain and …
accumulation of unbranched saturated very‐long‐chain fatty acids, particularly in brain and …
Extracellular vesicles as conveyors of membrane-derived bioactive lipids in immune system
Over the last 20 years, extracellular vesicles (EVs) have been established as an additional
way to transmit signals outside the cell. They are membrane-surrounded structures of …
way to transmit signals outside the cell. They are membrane-surrounded structures of …