The application of internal standards in quantitative and qualitative bioanalysis is a
commonly used procedure. They are usually isotopically labeled analogs of the analyte …

Deuteration of bioactive molecules is gaining more and more attention, especially after the
approval of the first deuterated drug (Austedo™) by the US Food and Drug Administration …

α-Ketoglutarate is a key biomolecule involved in a number of metabolic pathways─ most
notably the TCA cycle. Abnormal α-ketoglutarate metabolism has also been linked with …

A mild, versatile organophotoredox protocol has been developed for the preparation of
diverse, enantioenriched α-deuterated α-amino acids. Distinct from the well-established two …

A cobalt‐catalyzed deuteration of amidoacrylates using deuterated methanol afforded α, β‐
dideuterio‐α‐amino esters in excellent enantiomeric ratios (mostly> 95: 5) and almost …

Carbon-13 hyperpolarized pyruvate is about to become the next-generation contrast agent
for molecular magnetic resonance imaging of cancer and other diseases. Here, efficient and …

Peptides play essential roles in biological phenomena, and, thus, there is a growing interest
in detecting in vivo dynamics of peptide metabolisms. Dissolution-dynamic nuclear …

d-Amino acids such as d-alanine are substrates for bacterial peptidoglycan biosynthesis and
are selectively taken up by bacteria and not mammalian cells. Consequently, d-amino acid …

The ability to break down fructose is dependent on ketohexokinase (KHK) that
phosphorylates fructose to fructose-1-phosphate (F1P). We show that KHK expression is …

The conversion of [IrCl (COD)(IMes)](COD= cis, cis-1, 5-cyclooctadiene, IMes= 1, 3-bis (2, 4,
6-trimethyl-phenyl) imidazole-2-ylidene) in the presence of an excess of para-hydrogen (p …