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Machine learning-guided protein engineering
Recent progress in engineering highly promising biocatalysts has increasingly involved
machine learning methods. These methods leverage existing experimental and simulation …
machine learning methods. These methods leverage existing experimental and simulation …
Variant calling and benchmarking in an era of complete human genome sequences
Genetic variant calling from DNA sequencing has enabled understanding of germline
variation in hundreds of thousands of humans. Sequencing technologies and variant-calling …
variation in hundreds of thousands of humans. Sequencing technologies and variant-calling …
JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles
Abstract JASPAR (https://jaspar. elixir. no/) is a widely-used open-access database
presenting manually curated high-quality and non-redundant DNA-binding profiles for …
presenting manually curated high-quality and non-redundant DNA-binding profiles for …
Applying interpretable machine learning in computational biology—pitfalls, recommendations and opportunities for new developments
Recent advances in machine learning have enabled the development of next-generation
predictive models for complex computational biology problems, thereby spurring the use of …
predictive models for complex computational biology problems, thereby spurring the use of …
Signaling pathways involved in colorectal cancer: Pathogenesis and targeted therapy
Q Li, S Geng, H Luo, W Wang, YQ Mo, Q Luo… - … and Targeted Therapy, 2024 - nature.com
Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality
worldwide. Its complexity is influenced by various signal transduction networks that govern …
worldwide. Its complexity is influenced by various signal transduction networks that govern …
[PDF][PDF] Artificial intelligence and machine learning in pharmacological research: bridging the gap between data and drug discovery
Artificial intelligence (AI) has transformed pharmacological research through machine
learning, deep learning, and natural language processing. These advancements have …
learning, deep learning, and natural language processing. These advancements have …
Gene regulatory network reconstruction: harnessing the power of single-cell multi-omic data
Inferring gene regulatory networks (GRNs) is a fundamental challenge in biology that aims
to unravel the complex relationships between genes and their regulators. Deciphering these …
to unravel the complex relationships between genes and their regulators. Deciphering these …
Emerging applications of machine learning in genomic medicine and healthcare
The integration of artificial intelligence technologies has propelled the progress of clinical
and genomic medicine in recent years. The significant increase in computing power has …
and genomic medicine in recent years. The significant increase in computing power has …
To transformers and beyond: large language models for the genome
In the rapidly evolving landscape of genomics, deep learning has emerged as a useful tool
for tackling complex computational challenges. This review focuses on the transformative …
for tackling complex computational challenges. This review focuses on the transformative …
Harnessing deep learning for population genetic inference
In population genetics, the emergence of large-scale genomic data for various species and
populations has provided new opportunities to understand the evolutionary forces that drive …
populations has provided new opportunities to understand the evolutionary forces that drive …