Advanced metabolic engineering strategies for increasing artemisinin yield in Artemisia annua L.

Y Li, Y Yang, L Li, K Tang, X Hao, G Kai - Horticulture Research, 2024 - academic.oup.com
Artemisinin, also known as 'Qinghaosu', is a chemically sesquiterpene lactone containing an
endoperoxide bridge. Due to the high activity to kill Plasmodium parasites, artemisinin and …

[HTML][HTML] JA-mediated transcriptional regulation of secondary metabolism in medicinal plants

S Afrin, JJ Huang, ZY Luo - Science Bulletin, 2015 - Elsevier
Plants produce a wide spectrum of secondary metabolites that play critical roles in plant-
environment interactions and against biotic and abiotic stresses. Moreover, many secondary …

The jasmonate‐responsive AaMYC2 transcription factor positively regulates artemisinin biosynthesis in Artemisia annua

Q Shen, X Lu, T Yan, X Fu, Z Lv, F Zhang… - New …, 2016 - Wiley Online Library
The plant Artemisia annua is well known due to the production of artemisinin, a
sesquiterpene lactone that is widely used in malaria treatment. Phytohormones play …

GLANDULAR TRICHOME‐SPECIFIC WRKY 1 promotes artemisinin biosynthesis in Artemisia annua

M Chen, T Yan, Q Shen, X Lu, Q Pan, Y Huang… - New …, 2017 - Wiley Online Library
Artemisinin is a type of sesquiterpene lactone well known as an antimalarial drug, and is
specifically produced in glandular trichomes of Artemisia annua. However, the regulatory …

A basic leucine zipper transcription factor, AabZIP1, connects abscisic acid signaling with artemisinin biosynthesis in Artemisia annua

F Zhang, X Fu, Z Lv, X Lu, Q Shen, L Zhang, M Zhu… - Molecular plant, 2015 - cell.com
Artemisinin is a sesquiterpenoid especially synthesized in the Chinese herbal plant,
Artemisia annua, which is widely used in the treatment of malaria. Artemisinin accumulation …

The cold-induced transcription factor bHLH112 promotes artemisinin biosynthesis indirectly via ERF1 in Artemisia annua

L **ang, D Jian, F Zhang, C Yang, G Bai… - Journal of …, 2019 - academic.oup.com
Basic helix-loop-helix (bHLH) proteins are the second largest family of transcription factors
(TFs) involved in developmental and physiological processes in plants. In this study, 205 …

Transgenic approach to increase artemisinin content in Artemisia annua L.

K Tang, Q Shen, T Yan, X Fu - Plant cell reports, 2014 - Springer
Artemisinin, the endoperoxide sesquiterpene lactone, is an effective antimalarial drug
isolated from the Chinese medicinal plant Artemisia annua L. Due to its effectiveness …

Branch Pathway Blocking in Artemisia annua is a Useful Method for Obtaining High Yield Artemisinin

Z Lv, F Zhang, Q Pan, X Fu, W Jiang… - Plant and Cell …, 2016 - academic.oup.com
There are many biosynthetic pathways competing for the metabolic flux with the artemisinin
biosynthetic pathway in Artemisia annua L. To study the relationship between genes …

Overexpression of AaWRKY1 Leads to an Enhanced Content of Artemisinin in Artemisia annua

W Jiang, X Fu, Q Pan, Y Tang, Q Shen… - BioMed Research …, 2016 - Wiley Online Library
Artemisinin is an effective component of drugs against malaria. The regulation of artemisinin
biosynthesis is at the forefront of artemisinin research. Previous studies showed that …