CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
CGRP and the trigeminal system in migraine
S Iyengar, KW Johnson, MH Ossipov… - … : The Journal of Head …, 2019 - Wiley Online Library
Objective The goal of this narrative review is to provide an overview of migraine
pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) …
pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) …
Hypothalamic activation in cluster headache attacks
Background Cluster headache, one of the most severe pain syndromes in human beings, is
usually described as a vascular headache. However, the striking circadian rhythmicity of this …
usually described as a vascular headache. However, the striking circadian rhythmicity of this …
Trial of galcanezumab in prevention of episodic cluster headache
Background Episodic cluster headache is a disabling neurologic disorder that is
characterized by daily headache attacks that occur over periods of weeks or months …
characterized by daily headache attacks that occur over periods of weeks or months …
Diencephalic and brainstem mechanisms in migraine
Migraine is a common and complex brain disorder. Although it is clear that head pain is a
key manifestation of the disorder for most patients, what drives the activation of neuronal …
key manifestation of the disorder for most patients, what drives the activation of neuronal …
The trigeminovascular system in humans: pathophysiologic implications for primary headache syndromes of the neural influences on the cerebral circulation
Primary headache syndromes, such as cluster headache and migraine, are widely
described as vascular headaches, although considerable clinical evidence suggests that …
described as vascular headaches, although considerable clinical evidence suggests that …
Regulation of calcitonin gene‐related peptide secretion from trigeminal nerve cells by botulinum toxin type A: Implications for migraine therapy
PL Durham, R Cady, R Cady - … : The Journal of Head and Face …, 2004 - Wiley Online Library
Objective.—To determine the effect of botulinum toxin type A on calcitonin gene‐related
peptide secretion from cultured trigeminal ganglia neurons. Background.—The ability of …
peptide secretion from cultured trigeminal ganglia neurons. Background.—The ability of …
Phase 3 randomized, placebo-controlled study of galcanezumab in patients with chronic cluster headache: results from 3-month double-blind treatment
DW Dodick, PJ Goadsby, C Lucas, R Jensen… - …, 2020 - journals.sagepub.com
Objective To report efficacy and safety of galcanezumab in adults with chronic cluster
headache. Background Galcanezumab is a humanized monoclonal antibody that binds to …
headache. Background Galcanezumab is a humanized monoclonal antibody that binds to …
[BOOK][B] Headache in clinical practice
SD Silberstein - 2018 - taylorfrancis.com
The authors of the first edition worked together again to revise data for the second edition of
this popular volume. Based at three of the world's leading centers for the study and treatment …
this popular volume. Based at three of the world's leading centers for the study and treatment …
Cluster headache pathophysiology—insights from current and emerging treatments
Cluster headache is a debilitating primary headache disorder that affects approximately
0.1% of the population worldwide. Cluster headache attacks involve severe unilateral pain …
0.1% of the population worldwide. Cluster headache attacks involve severe unilateral pain …